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In Vivo Antihepatotoxic Effects of Ligularia fischeri var. spiciformis and the Identification of the Active Component, 3,4-Dicaffeoylquinic Acid
DC Field | Value | Language |
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dc.contributor.author | 박광균 | - |
dc.date.accessioned | 2017-10-26T06:34:00Z | - |
dc.date.available | 2017-10-26T06:34:00Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1096-620X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151006 | - |
dc.description.abstract | Pretreatment with a methanolic extract of Ligularia fischeri var. spiciformis (Compositae) herb inhibited hepatotoxicities caused by CCl4, D-galactosamine (GalN), α-naphthylisothiocyanate (ANIT), and DL-ethionine in rats. An ethyl acetate (EtOAc) extract fractionated from the methanolic extract showed a strong inhibitory effect. A major component, 3,4- dicaffeoylquinic acid (DCQA), isolated from the methanolic extract was examined for antihepatotoxicity. Pretreatment with DCQA (5 and 10 mg/kg, p.o.) significantly reduced serum aminotransferases (alanine and aspartate), sorbitol dehydrogenase, γ-glutamyltransferase, alkaline phosphatase, and lactate dehydrogenase activities during CCl4- or GalN-induced hepatotoxicity, suggesting that DCQA is a major principle for the antihepatotoxic activity of L. fischeri var. spiciformis. DCQA also partially restored bile flow and reduced total bilirubin and cholic acid concentrations in rats with ANIT-induced cholestasis. Treatment with DCQA inhibited the increase in triglyceride, cholesterol, and total lipids in DL-ethionine-induced fatty liver. These results support the traditionally held belief that this plant can be used for the treatment of jaundice and hepatic failure. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Mary Ann Liebert, Inc. | - |
dc.relation.isPartOf | JOURNAL OF MEDICINAL FOOD | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | antihepatotoxicity | - |
dc.subject.MESH | cholestasis | - |
dc.subject.MESH | 3,4-dicaffeoylquinic acid | - |
dc.subject.MESH | Ligularia fischeri var. spiciformis | - |
dc.title | In Vivo Antihepatotoxic Effects of Ligularia fischeri var. spiciformis and the Identification of the Active Component, 3,4-Dicaffeoylquinic Acid | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학교실) | - |
dc.contributor.googleauthor | Jongwon Choi | - |
dc.contributor.googleauthor | Jung-Kwan Park | - |
dc.contributor.googleauthor | Kyung-Tae Lee | - |
dc.contributor.googleauthor | Kwang-Kyun Park | - |
dc.contributor.googleauthor | Won-Bae Kim | - |
dc.contributor.googleauthor | Jin-Ha Lee | - |
dc.contributor.googleauthor | Hyun-Ju Jung | - |
dc.contributor.googleauthor | Hee-Juhn Park | - |
dc.identifier.doi | 10.1089/jmf.2005.8.348. | - |
dc.contributor.localId | A01429 | - |
dc.relation.journalcode | J01589 | - |
dc.identifier.eissn | 1557-7600 | - |
dc.identifier.pmid | 10.1089/jmf.2005.8.348. | - |
dc.identifier.url | http://online.liebertpub.com/doi/abs/10.1089/jmf.2005.8.348 | - |
dc.subject.keyword | antihepatotoxicity | - |
dc.subject.keyword | cholestasis | - |
dc.subject.keyword | 3,4-dicaffeoylquinic acid | - |
dc.subject.keyword | Ligularia fischeri var. spiciformis | - |
dc.contributor.alternativeName | Park, Kwang Kyun | - |
dc.citation.volume | 8 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 348 | - |
dc.citation.endPage | 352 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICINAL FOOD, Vol.8(3) : 348-352, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 43357 | - |
dc.type.rims | ART | - |
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