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방사열 자극실험쥐에서 Ketorolac과 Morphine의 병용투여 효과

Other Titles
 The Analgesic Interaction between Ketorolac and Morphine in Radiant Thermal Stimulation Rat 
Authors
 노장호  ;  최동훈  ;  이윤우  ;  윤덕미 
Citation
 Korean Journal of Pain (대한통증학회지), Vol.18(1) : 10-14, 2005 
Journal Title
 Korean Journal of Pain (대한통증학회지) 
ISSN
 2005-9159 
Issue Date
2005
Abstract
Background: Previous studies have suggested synergistic analgesic drug interactions between NSAIDs and opioids in neuropathic and inflammatory pain models. The aim of this study was to investigate the analgesic drug interaction between intraperitoneal (IP) ketorolac and morphine in radiant thermal stimulation rat. Methods: Initially, we assessed the withdrawal latency time of the hindpaw to radiant thermal stimulation every 15 min for 1 hour and every 30 min for next 1 hour after IP normal saline 5 ml (control group). The latency time was changed into percent maximal possible effect (%MPE). Next, IP dose response curves were established for the %MPE of morphine (0.3, 1, 3, 10 mg/kg) and ketorolac (3, 10, 30 mg/kg) to obtain the ED50 for each agent. And we confirmed that the IP morphine effect was induced by opioid receptor through IP morphine followed by IP naloxone. At last, we injected three doses of IP ketorolac (3, 10, 30 mg/kg) mixed with one dose of morphine (2 mg/kg) for fixed dose analysis. Results: IP morphine delayed the paw withdrawal latency time dose dependently, but not ketorolac. ED50 of IP morphine was 2.1 mg/kg. And the IP morphine effect was reversed to control level by IP naloxone. IP ketorolac + morphine combination showed no further additional effects on paw withdrawal latency time over morphine only group. Conclusions: IP ketorolac did not produce antinociceptive effect during radiant thermal stimulation. There was neither additional nor synergistic analgesic interaction between IP morphine and ketorolac in thermal stimulation rat.
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DOI
10.3344/kjp.2005.18.1.10
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
윤덕미(Yoon, Duck Mi)
이윤우(Lee, Youn Woo)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/150991
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