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Atopy and house dust mite sensitization as risk factors for asthma in children

 Jung-Wook Shin  ;  Ju-Hee Sue  ;  Tae-Won Song  ;  Kyung-Won Kim  ;  Eun-Soo Kim  ;  Myung Hyun Sohn  ;  Kyu-Earn Kim 
 YONSEI MEDICAL JOURNAL, Vol.46(5) : 629-634, 2005 
Journal Title
Issue Date
Animals ; Asthma/etiology* ; Child ; Child, Preschool ; Cross-Sectional Studies ; Dust* ; Female ; Humans ; Hypersensitivity/complications* ; Infant ; Infant, Newborn ; Male ; Mites/immunology* ; Retrospective Studies ; Risk Factors
Asthma ; atopy ; house dust mite
Asthma is commonly described as an atopic disease in childhood, but some cases of this disorder do not fit this description. The aim of this study was to evaluate the frequency of atopy, asthma, and sensitization to house dust mites in children with allergic symptoms. This study was performed at the Severance Hospital of Yonsei University with patients who visited the allergy clinic for evaluation of nonspecific upper respiratory symptoms, typical symptoms of asthma, or a general health workup. The patients were divided into three age groups: 0-3 years (group 1), 4-7 years (group 2), and 8-12 years (group 3). Of the 1,244 children examined, 844 (67.8%) were atopic and 400 (32.2%) were non-atopic. The frequency of atopy and asthma increased with age. Asthma was diagnosed in the same proportion (64%) of atopic and non-atopic children. As risk factors for asthma symptoms, the positive values of house dust mite (HDM) sensitivity were significantly increased in groups 1, 2, and 3 to 53.5%, 68.9%, and 80.2%, respectively. A significant difference between the percentage of asthmatics sensitized to HDM and that of asthmatics not sensitized to HDM was found only in group 3. In conclusion, asthma is related to atopy with increasing age, and house dust mite sensitization seems to be an important determinant of asthma in older children in Korea.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Kyu Earn(김규언)
Kim, Eun Soo(김은수)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Song, Tae Won(송태원)
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