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BCG 예방접종을 받은 개체에서 유도되어 있는 결핵균 균체항원에 특정한 CD8+T 세포의 보호 면역반응
DC Field | Value | Language |
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dc.contributor.author | 조상래 | - |
dc.contributor.author | 조성애 | - |
dc.date.accessioned | 2017-10-26T06:30:59Z | - |
dc.date.available | 2017-10-26T06:30:59Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1738-3536 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/150911 | - |
dc.description.abstract | Background : The immune responses mediated by CD8+T cells are known to be significant in controlling M. tuberculosis infections. In order to determine the role of cytotoxic CD8+T cells in the protective immune mechanism in latently infected subjects, this study examined whether or not the cytotoxic immune responses of CD8+T cells specific to the M. tuberculosis somatic antigens are induced in BCG vaccinated healthy subjects. Methods : Cytotoxicity and IFN-γ elispot assays were used to investigate the activities of CD8+T cells specific for the thyA30-38 peptide epitope in circulating peripheral blood mononuclear cells (PBMC) from BCG-vaccinated HLA-A*0201 and A*0206 subjects. Results : The results indicate the cytotoxic and IFN-γ immune responses of CD8+T cells specific for thyA30-38 were induced in BCG vaccinated healthy subjects. Conclusion : The cytotoxic and IFN-γ responses by CD8+T cells specific for the M. tuberculosis somatic antigens are induced in BCG-vaccinated subjects, and appear to be involved in the protective immune mechanism in latently infected people against a M. tuberculosis infection. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한결핵 및 호흡기학회 | - |
dc.relation.isPartOf | TUBERCULOSIS AND RESPIRATORY DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | CD8+T cells | - |
dc.subject.MESH | cytotoxicity | - |
dc.subject.MESH | M. tuberculosis somatic antigens | - |
dc.title | BCG 예방접종을 받은 개체에서 유도되어 있는 결핵균 균체항원에 특정한 CD8+T 세포의 보호 면역반응 | - |
dc.title.alternative | M.tuberculosis Somatic Antigen Specific CD8+T cell Responses in BCG-Vaccinated Subjects | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | 조장은 | - |
dc.contributor.googleauthor | 조상래 | - |
dc.contributor.googleauthor | 이경화 | - |
dc.contributor.googleauthor | 박승규 | - |
dc.contributor.googleauthor | 조성애 | - |
dc.identifier.doi | OAK-2005-03876 | - |
dc.contributor.localId | A03824 | - |
dc.contributor.localId | A03835 | - |
dc.relation.journalcode | J02761 | - |
dc.identifier.eissn | 2005-6184 | - |
dc.relation.journalsince | 2004~ | - |
dc.relation.journalbefore | ~2004 Tuberculosis and Respiratory Diseases (결핵 및 호흡기질환) | - |
dc.subject.keyword | CD8+T cells | - |
dc.subject.keyword | cytotoxicity | - |
dc.subject.keyword | M. tuberculosis somatic antigens | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.alternativeName | Cho, Sung Ae | - |
dc.citation.volume | 59 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 272 | - |
dc.citation.endPage | 278 | - |
dc.identifier.bibliographicCitation | TUBERCULOSIS AND RESPIRATORY DISEASES, Vol.59(3) : 272-278, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 42761 | - |
dc.type.rims | ART | - |
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