Cited 58 times in
Comparison of drug resistance genotypes between Beijing and non-Beijing family strains of Mycobacterium tuberculosis in Korea
DC Field | Value | Language |
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dc.contributor.author | 조상래 | - |
dc.date.accessioned | 2017-10-26T06:30:50Z | - |
dc.date.available | 2017-10-26T06:30:50Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0167-7012 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/150904 | - |
dc.description.abstract | The frequency of resistance genotypes among Beijing and non-Beijing strains was compared using a reverse blot hybridization assay to detect mutations within genes associated with rifampicin (rpoB) and isoniazid (katG, inhA, and ahpC) resistance. Of the 743 Mycobacterium tuberculosis isolates, 569 (77%) belonged to Beijing family. The proportion of Beijing strains was significantly higher among MDR-TB isolates than among drug-susceptible strains (82% vs. 72%, p < 0.01). Genotype analysis of the rpoB gene revealed significantly lower rates of the Ser531Leu mutation rate among Beijing vs. non-Beijing MDR-TB strains (41% vs. 66%, p < 0.005). While the mutation for Ser315Thr in the katG gene was more common among Beijing vs. non-Beijing family strains (65% vs. 50%, p < 0.01), the mutation rate of promoter region of the inhA gene was lower among Beijing strains compared with non-Beijing strains (14% vs. 25%, p < 0.05). Reverse hybridization successfully detected over 80% of isoniazid-resistant strains and over 92% of rifampicin-resistant strains among Korean isolates. Significant differences in mutation rates in the rpoB, katG, and inhA genes between Beijing strains and non-Beijing strains could explain discrepancies in mutation rates of genotypes in different countries. Reverse hybridization was useful for rapid detection of isoniazid and rifampicin resistant strains. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Biomedical | - |
dc.relation.isPartOf | JOURNAL OF MICROBIOLOGICAL METHODS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antitubercular Agents/pharmacology* | - |
dc.subject.MESH | Bacterial Proteins/genetics | - |
dc.subject.MESH | China | - |
dc.subject.MESH | Drug Resistance, Bacterial/genetics* | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea/epidemiology | - |
dc.subject.MESH | Microbial Sensitivity Tests | - |
dc.subject.MESH | Mutation | - |
dc.subject.MESH | Mycobacterium tuberculosis/classification* | - |
dc.subject.MESH | Mycobacterium tuberculosis/drug effects* | - |
dc.subject.MESH | Mycobacterium tuberculosis/genetics | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Tuberculosis, Multidrug-Resistant/epidemiology* | - |
dc.subject.MESH | Tuberculosis, Multidrug-Resistant/microbiology | - |
dc.subject.MESH | Tuberculosis, Pulmonary/epidemiology* | - |
dc.subject.MESH | Tuberculosis, Pulmonary/microbiology | - |
dc.title | Comparison of drug resistance genotypes between Beijing and non-Beijing family strains of Mycobacterium tuberculosis in Korea | - |
dc.type | Article | - |
dc.publisher.location | Netherlands | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Young Kil Park | - |
dc.contributor.googleauthor | Sonya Shin | - |
dc.contributor.googleauthor | Sungweon Ryu | - |
dc.contributor.googleauthor | Sang Nae Cho | - |
dc.contributor.googleauthor | Won-Jung Koh | - |
dc.contributor.googleauthor | O Jung Kwon | - |
dc.contributor.googleauthor | Young Soo Shim | - |
dc.contributor.googleauthor | Woo Jin Lew | - |
dc.contributor.googleauthor | Gill Han Bai | - |
dc.identifier.doi | 10.1016/j.mimet.2005.03.002 | - |
dc.contributor.localId | A03824 | - |
dc.relation.journalcode | J01592 | - |
dc.identifier.eissn | 1872-8359 | - |
dc.identifier.pmid | 15893392 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0167701205000795 | - |
dc.subject.keyword | ahpC gene | - |
dc.subject.keyword | Beijing family | - |
dc.subject.keyword | inhA gene | - |
dc.subject.keyword | katG gene | - |
dc.subject.keyword | Mycobacterium tuberculosis | - |
dc.subject.keyword | rpoB gene | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.citation.volume | 63 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 165 | - |
dc.citation.endPage | 172 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROBIOLOGICAL METHODS, Vol.63(2) : 165-172, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 42753 | - |
dc.type.rims | ART | - |
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