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투베르쿨린 검사가 결핵에 대한 체외 IFN-γ 검사 결과에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | 조상래 | - |
dc.date.accessioned | 2017-10-26T06:30:49Z | - |
dc.date.available | 2017-10-26T06:30:49Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1738-3536 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/150903 | - |
dc.description.abstract | Background : Recently, two commercialized whole Background -blood assays, QuantiFERONⓇ-TB Gold (QFT) and T SPOT-TBⓇ(SPOT), which measure the IFN-γ released in the whole blood after being incubation with mycobacterial antigens, were approved for the diagnosis of a latent tuberculosis infection (LTBI). However, there is data on whether or not the previously used PPD skin tests (TST) have any influence on the diagnostic ability of these ex-vivo IFN-γ assays. Methods : Forty Methods -six 15 year-old students who did not appear to be infected with Mycobacterium tuberculosis were enrolled in this study. The peripheral blood was collected and used for two IFN-γ assays. The IFN-γ assays and TST were performed at the baseline (1st). The TST was repeated two months later (2nd), and the IFN-γ assays were repeated two (2nd) and four months (3rd) later only in those subjects who had negative results at the baseline in both the IFN-γ assays and TST. An induration size > 10 mm was considered to be positive in the TST. Results : The mean TST value was 3.1 ± 5.4 mm (range: 0 Results -20). Of the 46 subjects examined, 13 subjects (28.3%) showed positive results in the two-step TST. Nine (19.6%) were SPOT-positive and only one (2.2%) was QFT-positive. The 2nd and 3rd QFT were carried out in 23 and 25 all-negative subjects, respectively, and all showed negative results. The 2nd SPOT was performed in 23 subjects and only one (4.3%) showed a weak-positive result. Conclusion : Even though there were some discrepancies in th Conclusion e results of the two ex-vivo IFN-γ assays, it appears that their results were not influenced by a previous TST carried out in two or four months earlier. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한결핵 및 호흡기학회 | - |
dc.relation.isPartOf | TUBERCULOSIS AND RESPIRATORY DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Latent tuberculosis infection | - |
dc.subject.MESH | Interferon-gamma assay | - |
dc.subject.MESH | Tuberculin skin test | - |
dc.subject.MESH | Purified Protein Derivative | - |
dc.title | 투베르쿨린 검사가 결핵에 대한 체외 IFN-γ 검사 결과에 미치는 영향 | - |
dc.title.alternative | Effect of Tuberculin Skin Test on Ex-vivo Interferon-gamma Assay for Latent Tuberculosis Infection | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | 이정연 | - |
dc.contributor.googleauthor | 최희진 | - |
dc.contributor.googleauthor | 조상래 | - |
dc.contributor.googleauthor | 박이내 | - |
dc.contributor.googleauthor | 오연목 | - |
dc.contributor.googleauthor | 이상도 | - |
dc.contributor.googleauthor | 김우성 | - |
dc.contributor.googleauthor | 김동순 | - |
dc.contributor.googleauthor | 김원동 | - |
dc.contributor.googleauthor | 심태선 | - |
dc.identifier.doi | OAK-2005-03870 | - |
dc.contributor.localId | A03824 | - |
dc.relation.journalcode | J02761 | - |
dc.identifier.eissn | 2005-6184 | - |
dc.relation.journalsince | 2004~ | - |
dc.relation.journalbefore | ~2004 Tuberculosis and Respiratory Diseases (결핵 및 호흡기질환) | - |
dc.subject.keyword | Latent tuberculosis infection | - |
dc.subject.keyword | Interferon-gamma assay | - |
dc.subject.keyword | Tuberculin skin test | - |
dc.subject.keyword | Purified Protein Derivative | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.citation.volume | 59 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 406 | - |
dc.citation.endPage | 412 | - |
dc.identifier.bibliographicCitation | TUBERCULOSIS AND RESPIRATORY DISEASES, Vol.59(4) : 406-412, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 42752 | - |
dc.type.rims | ART | - |
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