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Alpha(2b)-아드레날린 수용체 Insertion/Deletion 유전자 다형성과 관동맥질환과의 연관성
DC Field | Value | Language |
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dc.contributor.author | 고영국 | - |
dc.contributor.author | 박찬미 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 조은영 | - |
dc.contributor.author | 최정란 | - |
dc.contributor.author | 홍정애 | - |
dc.date.accessioned | 2017-10-26T06:16:04Z | - |
dc.date.available | 2017-10-26T06:16:04Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/150730 | - |
dc.description.abstract | BACKGROUND AND OBJECTIVES: Cardiovascular disease (CVD) is a complex multigenic disorder, with significant inheritable elements having important roles relating to environmental factors. Recently, the alpha 2 adrenoceptor (alpha(2)-AR) gene has been reported to be involved in the development of coronary artery disease (CAD). The aim of this study was to investigate the relationships between an insertion/deletion (I/D) in alpha(2B)-AR and CAD in Korean subjects. SUBJECTS AND METHODS: The alpha(2B)-AR I/D polymorphism, which was located in the third intracellular loop of the receptor polypeptide, was examined in 292 patients (M:F=219:73) with CAD and 151 healthy control subjects (M:F=70:81) who visited the Cardiovascular Genome Center in Yonsei Cardiovascular Hospital. RESULTS: In the patient group, 77 men (35.1%) and 26 women (35.6%) had the I/I genotype; 105 men (47.9%) and 39 women (53.4%) a heterozygous genotype and 37 (17.0%) and 8 (11.0%) the D/D genotype. In the controls, 23 men (32.8%) and 29 women (35.8%) had the I/I genotype; 38 (54.3%) and 39 (48.1%) the I/D genotype and 9 (12.9%) and 13 (16.1%) the D/D genotype. There were no differences in the genotype frequencies between the patient and control groups, either in men or women. From a logistical regression analysis, the alpha(2B)-AR genotype was not significantly associated with CAD in our study group. CONCLUSION: The alpha(2B)-AR I/D polymorphism is not a risk factor for CAD in the Korean population. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | Korean Society of Circulation | - |
dc.relation.isPartOf | KOREAN CIRCULATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Coronary artery disease;α2B-adrenoceptors;Polymorphism, genetic | - |
dc.title | Alpha(2b)-아드레날린 수용체 Insertion/Deletion 유전자 다형성과 관동맥질환과의 연관성 | - |
dc.title.alternative | An Insertion/Deletion Polymorphism in the α2B-Adrenoceptor Gene is not a Genetic Risk Factor for Coronary Artery Disease in the Korean Population | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | 최정란 | - |
dc.contributor.googleauthor | 박찬미 | - |
dc.contributor.googleauthor | 홍정애 | - |
dc.contributor.googleauthor | 배수진 | - |
dc.contributor.googleauthor | 엄상미 | - |
dc.contributor.googleauthor | 조은영 | - |
dc.contributor.googleauthor | 고영국 | - |
dc.contributor.googleauthor | 박현영 | - |
dc.contributor.googleauthor | 장양수 | - |
dc.identifier.doi | OAK-2005-04520 | - |
dc.contributor.localId | A00127 | - |
dc.contributor.localId | A01708 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A03882 | - |
dc.contributor.localId | A04177 | - |
dc.contributor.localId | A04429 | - |
dc.relation.journalcode | J01952 | - |
dc.identifier.eissn | 1738-5555 | - |
dc.relation.journalsince | 2005~ | - |
dc.relation.journalbefore | ~2004 Korean Circulation Journal (순환기) | - |
dc.subject.keyword | Coronary artery disease;α2B-adrenoceptors;Polymorphism, genetic | - |
dc.contributor.alternativeName | Ko, Young Guk | - |
dc.contributor.alternativeName | Park, Chan Mi | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Cho, Eun Young | - |
dc.contributor.alternativeName | Choi, Jung Ran | - |
dc.contributor.alternativeName | Hong, Jeong Ae | - |
dc.citation.volume | 35 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 215 | - |
dc.citation.endPage | 220 | - |
dc.identifier.bibliographicCitation | KOREAN CIRCULATION JOURNAL, Vol.35(3) : 215-220, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 44240 | - |
dc.type.rims | ART | - |
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