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고삼투압 자극이 호산구의 활성화에 미치는 영향

Other Titles
 Effects of Hyperosmolar Stimuli on Activation ofHuman Eosinophilic Leukaemia EoL-1 Cells 
 권병철  ;  김은수  ;  김경원  ;  송태원  ;  손명현  ;  신명헌  ;  김규언 
 Korean Journal of Pediatrics, Vol.48(8) : 881-885, 2005 
Journal Title
 Korean Journal of Pediatrics 
Issue Date
Exercise-induced asthma ; Hyperosmolar ; EoL-1 cells
Exercise-induced asthma ; Hyperosmolar ; EoL-1 cells
Purpose: Airway dehydration and subsequent hyperosmolarity of periciliary fluid are considered critical events in exercise-induced bronchoconstriction. The aim of this study was to establish if a hyperosmolar challenge could induce activation of eosinophils. Methods: Human eosinophilic leukaemic cell lines, EoL-1 cells were incubated with hyperosmolar solutions for 15 minutes. Activation of EoL-1 cells was monitored by degranulation and superoxide anion production. In addition, we examined surface expression of CD69 and ICAM-1. Results: Hyperosmolar stimuli didn’t induce superoxide anion production and degranulation. In addition, EoL-1 cells cultured with hyperosmolar medium at 930 mOsm/kg H2O resulted in no significant increment in fluorescent intensity of CD69 and ICAM-1 expression compared with results for cells incubated with isomolar medium. Conclusion: We found that hyperosmolar stimuli don’t cause activation of EoL-1 cells, but further studies are required to determine the role of eosinophil in the mechanism of exercise-induced asthma.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Kyu Earn(김규언)
Kim, Eun Soo(김은수)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Song, Tae Won(송태원)
Shin, Myeong Heon(신명헌) ORCID logo https://orcid.org/0000-0001-8207-6110
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