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A Carcinoembryonic Antigen-Secreting Adenocarcinoma Arising in Tailgut Cyst : Clinical Implications of Carcinoembryonic Antigen

Authors
 Byoung Chul Cho  ;  Nam Kyu Kim  ;  Beom Jin Lim  ;  Sang Ook Kang  ;  Ju Hyuk Sohn  ;  Jae Kyung Roh  ;  Sang Tae Choi  ;  Sung Ai Kim  ;  Se Eun Park 
Citation
 YONSEI MEDICAL JOURNAL, Vol.46(4) : 555-561, 2005 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2005
MeSH
Adenocarcinoma/blood ; Adenocarcinoma/pathology ; Adenocarcinoma/therapy* ; Adult ; CA-19-9 Antigen/blood ; Carcinoembryonic Antigen/blood* ; Cysts/blood ; Cysts/pathology ; Cysts/therapy* ; Female ; Hamartoma/blood ; Hamartoma/pathology ; Hamartoma/therapy* ; Humans ; Rectal Neoplasms/blood ; Rectal Neoplasms/pathology ; Rectal Neoplasms/therapy* ; Sacrococcygeal Region
Keywords
Tailgut cyst ; developmental cyst ; presacral space ; adenocarcinoma ; carcinoembryonic antigen
Abstract
Tailgut cysts (TGCs) are rare congenital cysts that occur in the retrorectal or presacral spaces. Although most tailgut cysts have been reported as benign, there have been at least 9 cases associated with malignant change. We report herein on an unusual case of a 40-year-old woman with a carcinoembryonic antigen (CEA)-producing adenocarcinoma arising within a TGC who underwent surgical resection and local radiation therapy. Despite the complete resection, metastatic adenocarcinoma developed five months after surgery. CEA-producing adenocarcinoma from a TGC is extremely rare and only two cases, including this case, have been reported in the English medical literature. Besides CEA, the serum levels of CA 19-9 became markedly elevated in this patient. Given that the serum CEA level decreased to the normal range after complete resection of tumor and that the tumor recurrence was associated with a rebound of the CEA serum level, our case shows that serial measurements of serum CEA can be used for treatment planning and for assessing the patient's treatment response for this rare disease.
Files in This Item:
T200500722.pdf Download
DOI
10.3349/ymj.2005.46.4.555
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Kim, Sung Ai(김성애)
Park, Se Eun(박세은)
Sohn, Joo Hyuk(손주혁) ORCID logo https://orcid.org/0000-0002-2303-2764
Cho, Byoung Chul(조병철) ORCID logo https://orcid.org/0000-0002-5562-270X
Choi, Sang Tae(최상태)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/150550
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