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Can azathioprine and steroids alter the progression of severe Henoch-Schönlein nephritis in children?

Authors
 Jae Il Shin  ;  Jee Min Park  ;  Youn Ho Shin  ;  Ji Hong Kim  ;  Jae Seung Lee  ;  Pyung Kil Kim  ;  Hyeon Joo Jeong 
Citation
 PEDIATRIC NEPHROLOGY, Vol.20(8) : 1087-1092, 2005 
Journal Title
PEDIATRIC NEPHROLOGY
ISSN
 0931-041X 
Issue Date
2005
MeSH
Adolescent ; Azathioprine/administration & dosage* ; Biopsy ; Child ; Child, Preschool ; Cohort Studies ; Drug Therapy, Combination ; Female ; Glomerulonephritis/drug therapy* ; Glomerulonephritis/pathology ; Humans ; Kidney/pathology ; Male ; Methylprednisolone/administration & dosage* ; Prednisolone/administration & dosage* ; Proteinuria/drug therapy ; Purpura, Schoenlein-Henoch/complications* ; Purpura, Schoenlein-Henoch/drug therapy* ; Purpura, Schoenlein-Henoch/pathology ; Retrospective Studies
Keywords
Azathioprine ; Henoch-Schönlein nephritis ; Nephrotic-range proteinuria ; Steroids
Abstract
To evaluate the effect of azathioprine with steroids on the clinical course and histologic parameters of severe Henoch-Schönlein nephritis (HSN), 20 patients with a median age of 9.3 years (range 4.4–17 years) and a follow-up period of 4.8 years (range 1–14 years) were included in this study. The patients were divided into two groups. Ten patients received azathioprine with steroids for 8 months (group A), and the other ten received steroids alone (group B). All patients underwent renal biopsy at presentation, and ten of them who were treated with azathioprine underwent follow-up biopsy after therapy. Six patients in group A achieved clinical remission, and the remaining four showed minor urinary abnormalities at the latest observation. The histological grades of the International Study of Kidney Disease in Children (ISKDC) improved in four of the ten patients, and the activity index decreased significantly from 6.8±2.0 to 4.3±2.3 (p=0.016). In group B, however, four patients had normal urine and renal function; two had minor urinary abnormalities; one had active renal disease, and three had chronic renal insufficiency, at the latest observation. The combination treatment of azathioprine and steroids may be beneficial in ameliorating histopathological features and improving the clinical course of severe HSN.
Full Text
http://link.springer.com/article/10.1007%2Fs00467-005-1869-x
DOI
10.1007/s00467-005-1869-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ji Hong(김지홍) ORCID logo https://orcid.org/0000-0001-5352-5423
Lee, Jae Seung(이재승)
Jeong, Hyeon Joo(정현주) ORCID logo https://orcid.org/0000-0002-9695-1227
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/150525
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