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병기 T1, 분화도 3 방광암에 있어서 cyclooxygenase-2와 p53의 예후 판정의 가치
DC Field | Value | Language |
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dc.contributor.author | 권수미 | - |
dc.contributor.author | 정병하 | - |
dc.contributor.author | 홍성준 | - |
dc.date.accessioned | 2017-10-26T05:56:09Z | - |
dc.date.available | 2017-10-26T05:56:09Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0494-4747 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/150498 | - |
dc.description.abstract | Purpose: The prognostic value of p53 remains controversial in stage T1, grade III (T1GIII) transitional cell carcinomas (TCC) of the bladder. Recent studies have reported increased expression of cyclooxygenase-2 (COX-2) in bladder cancer. The prognostic values of p53 and COX-2 were compared in T1GIII TCC of the bladder. Materials and Methods: Among 57 consecutive patients, diagnosed with T1GIII TCC of the bladder by transurethral resection (TURB), 37 were eligible for this study. Exclusion criteria included; the first TURB performed elsewhere, no or inadequate (less than 6 weeks) bacillus Calmette- Guerin treatment and postoperative follow-up of less than 1 year. The expressions of p53 and COX-2 were evaluated by immunohistochemical staining of TURB tissues. Possible correlations of the p53 and COX-2 expressions with the clinicopathological features, such as age, shape and multiplicity of tumor, recurrence and progression, were examined. Results: During a mean follow-up of 27 months, the disease recurred in 43.2% and progressed in 16.2%. Of the 37 specimens, 31 (83.8%) and 16 (43.2%) stained positive for COX-2 and p53 expressions, respectively. There were no significant differences in age, shape and multiplicity of the tumors, recurrence-free survival and progression-free survival between the p53 positive and negative groups. However, the recurrence-free and progression-free survivals were significantly lower in the COX-2 positive than in the COX-2 negative group (p=0.049 and p=0.027, respectively). When combined, p53 and COX-2 more accurately predicted recurrence than COX-2 alone (p=0.036), but not the progression (p=0.776). Conclusions: In the pathologically homogeneous group of T1GIII TCC of the bladder, COX-2 was superior to p53 in predicting the prognosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한비뇨기과학회 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF UROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Bladder cancer | - |
dc.subject.MESH | Cyclooxygenase 2 | - |
dc.subject.MESH | p53 genes | - |
dc.subject.MESH | Recurrence | - |
dc.subject.MESH | Disease progression | - |
dc.title | 병기 T1, 분화도 3 방광암에 있어서 cyclooxygenase-2와 p53의 예후 판정의 가치 | - |
dc.title.alternative | Prognostic Value of Cyclooxygenase-2 and p53 Expression in Stage T1 Grade III Bladder Cancer | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | 홍성준 | - |
dc.contributor.googleauthor | 이중식 | - |
dc.contributor.googleauthor | 정병하 | - |
dc.contributor.googleauthor | 권수미 | - |
dc.contributor.googleauthor | 김선일 | - |
dc.identifier.doi | OAK-2005-03809 | - |
dc.contributor.localId | A00222 | - |
dc.contributor.localId | A03607 | - |
dc.contributor.localId | A04402 | - |
dc.relation.journalcode | J02135 | - |
dc.relation.journalsince | 1983~2009 | - |
dc.relation.journalafter | 2009~ Korean Journal of Urology | - |
dc.subject.keyword | Bladder cancer | - |
dc.subject.keyword | Cyclooxygenase 2 | - |
dc.subject.keyword | p53 genes | - |
dc.subject.keyword | Recurrence | - |
dc.subject.keyword | Disease progression | - |
dc.contributor.alternativeName | Kwon, Soo Mee | - |
dc.contributor.alternativeName | Chung, Byung Ha | - |
dc.contributor.alternativeName | Hong, Sung Joon | - |
dc.citation.volume | 46 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 785 | - |
dc.citation.endPage | 791 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF UROLOGY, Vol.46(8) : 785-791, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 42778 | - |
dc.type.rims | ART | - |
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