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An Unusual Case of Spontaneous Remission of Hodgkin's Disease after a Single Cycle of COPP-ABV Chemotherapy Followed by Infectious Complications

 Seungmin Bang  ;  June-Won Cheong  ;  Woo Ick Yang  ;  Jee Sook Hahn 
 Yonsei Medical Journal, Vol.46(3) : 425-430, 2005 
Journal Title
 Yonsei Medical Journal 
Issue Date
Adult ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage* ; Bleomycin/administration & dosage* ; Cyclophosphamide/administration & dosage* ; Doxorubicin/administration & dosage* ; Hodgkin Disease/complications* ; Hodgkin Disease/drug therapy* ; Humans ; Male ; Pneumonia/complications* ; Prednisone/administration & dosage* ; Procarbazine/administration & dosage* ; Remission, Spontaneous ; Vinblastine/administration & dosage* ; Vincristine/administration & dosage*
Spontaneous remission ; Hodgkin's disease ; incomplete chemotherapy
Advanced Hodgkin's disease is usually treated with six or more cycles of combination chemotherapy. Spontaneous regression of the cancer is very rarely reported in patients with Hodgkin's disease. We present an unusual case of a patient with Hodgkin's disease who experienced complete remission with a single cycle of chemotherapy, followed by pneumonia. The case was a 36-year-old man diagnosed with stage IVB mixed cellularity Hodgkin's disease in November 2000. After treatment with one cycle of COPP-ABV (cyclophosphamide, vincristine, procarbazine, prednisone, doxorubicin, bleomycin, and vinblastine) chemotherapy without bleomycin, the patient developed interstitial pneumonia and was cared in the intensive care unit (ICU) for two months. Follow-up chest computerized tomography (CT), performed during the course of ICU care, revealed markedly improved mediastinal lymphomatous lesions. Furthermore, follow-up whole body CT and 18-fluorodeoxyglucose positron emission tomography showed complete disappearance of the lymphomatous lesions. Four years later, the patient is well and without relapse. This report is followed by a short review of the literature on spontaneous regression of Hodgkin's disease. To the best of our knowledge, this is the first case report of spontaneous remission of Hodgkin's disease in Korea.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Bang, Seungmin(방승민) ORCID logo https://orcid.org/0000-0001-5209-8351
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Cheong, June-Won(정준원) ORCID logo https://orcid.org/0000-0002-1744-0921
Hahn, Jee Sook(한지숙)
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