0 441

Cited 0 times in

Combined Effects of Losartan and Pravastatin on Interstitial Inflammation and Fibrosis in Chronic Cyclosporine-Induced Nephropathy

Authors
 Can Li  ;  Bo Kyung Sun  ;  Sun Woo Lim  ;  Joon Chang Song  ;  Shin-Wook Kang  ;  Yu Seun Kim  ;  Duk Hee Kang  ;  Jung Ho Cha  ;  Jin Kim  ;  Chul Woo Yang 
Citation
 TRANSPLANTATION, Vol.79(11) : 1522-1529, 2005 
Journal Title
TRANSPLANTATION
ISSN
 0041-1337 
Issue Date
2005
MeSH
Animals ; C-Reactive Protein/metabolism ; Cyclosporine/pharmacology* ; Cyclosporine/toxicity* ; Disease Models, Animal ; Fibrosis ; Inflammation ; Kidney/drug effects ; Kidney/physiopathology ; Kidney Diseases/chemically induced* ; Kidney Diseases/pathology ; Kidney Diseases/prevention & control ; Losartan/pharmacology ; Male ; Pravastatin/pharmacology* ; Rats ; Rats, Sprague-Dawley
Keywords
15940041
Abstract
BACKGROUND: Statins and angiotensin II type I receptor blockers have synergistic effects on vascular smooth-muscle-cell proliferation and the progression of renal diseases. We evaluated whether combined treatment with losartan (LSRT) and pravastatin (PRVT) affords superior protection compared with their respective monotherapies in treating chronic cyclosporine (CsA)-induced nephropathy in rats.
METHODS: Rats maintained on a low salt diet were given vehicle, CsA (15 mg/kg), CsA and LSRT (10 mg/kg), CsA and PRVT (5 mg/kg), or a combination of CsA, LSRT, and PRVT for 28 days. Basic parameters (renal function, systolic blood pressure, serum high-sensitivity C-reactive protein [hs-CRP], and lipid profiles), histopathology (arteriolopathy, tubulointerstitial fibrosis, and inflammatory cell infiltration), and inflammatory and fibrotic factors (intrarenal CRP, angiotensin II, osteopontin, and transforming growth factor [TGF]-beta1) were studied.
RESULTS: LSRT or PRVT treatment significantly attenuated the histopathologic changes induced by CsA, and combined treatment with LSRT and PRVT further decreased these parameters compared with giving each drug alone. Increased levels of angiotensin II, intrarenal CRP, osteopontin, and TGF-beta1 in CsA-treated rat kidney were reduced by treatment with either LSRT or PRVT and were further decreased by the combination of the two drugs. There were no significant differences in systolic blood pressure or serum lipid parameters between groups.
CONCLUSIONS: Combined treatment with LSRT and PRVT provided synergistic effects in attenuating inflammatory and fibrotic processes in a rat model of chronic CsA-induced nephropathy, and this effect was independent of their hypolipidemic and hypotensive actions.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00007890-200506150-00010&LSLINK=80&D=ovft
DOI
OAK-2005-03609
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/150023
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links