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Efficacy and safety of the ketogenic diet for intractable childhood epilepsy: Korean multicentric experience

 Hoon Chul Kang  ;  Yong Joo Kim  ;  Dong Wook Kim  ;  Heung Dong Kim 
 EPILEPSIA, Vol.46(2) : 272-279, 2005 
Journal Title
Issue Date
Adolescent ; Child ; Clinical Protocols ; Cross-Cultural Comparison ; Diet Therapy/methods ; Dietary Fats/adverse effects* ; Dietary Fats/metabolism ; Dietary Fats/therapeutic use* ; Epilepsy/diagnosis ; Epilepsy/diet therapy* ; Epilepsy/metabolism ; Female ; Follow-Up Studies ; Humans ; Ketosis/etiology ; Ketosis/metabolism* ; Korea ; Male ; Prognosis ; Treatment Outcome
Efficacy ; Safety ; Prognosis ; Ketogenic diet ; Intractable childhood epilepsy
PURPOSE: We wished to evaluate the efficacy and safety of the ketogenic diet (KD), and we also evaluated the prognosis of the patients after successful discontinuation of the diet in infants, children, and adolescents with refractory epilepsy. METHODS: This was a retrospective study of epilepsy patients treated with the KD during 1995 through 2003 at the Korean multicenters. Outcome measures included seizure frequency, electroencephalography (EEG), adverse reactions, and antiepileptic drug (AED) number. The variables related to the efficacy and prognosis also were analyzed. RESULTS: The outcomes of the 199 patients enrolled in this study at 6 and 12 months after the diet were revealed; 68% and 46% of patients remained on the diet, 58% and 41% showed a reduction of seizure frequency of >50%, including 33% and 25% who became seizure free, respectively. Finally, 66 (34%) of 199 patients successfully completed or maintained the diet. EEGs showed an improvement in background in 40 (72.7%) of 55 patients and a reduction in generalized and focal discharges in 41 (57.7%) of 71 and 15 (33.3%) of 45 patients. Most complications were mild, but five patients died during the KD. No significant variables were related to the efficacy, but those with symptomatic (p=0.047) and partial epilepsies (p=0.073) showed more frequent relapse after completion of the diet. CONCLUSIONS: The KD is a safe and effective alternative therapy for intractable childhood epilepsy in Korea, although the customary diet contains substantially less fat than traditional Western diets, but life-threatening complications should be monitored closely during follow-up.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hoon Chul(강훈철) ORCID logo https://orcid.org/0000-0002-3659-8847
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
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