326 621

Cited 0 times in

성인의 복잡성 복강내 감염증의 치료에서 Ertapenem 단독투여와 Ceftriaxone과Metronidazole 병용투여의 안전성과 유효성 평가를위한 다기관, 공개, 무작위, 비교 임상연구

Other Titles
 A Randomized, Controlled, Open, Multi-Center Clinical Trial Comparing Ertapenem versus Ceftriaxone plus Metronidazole for the Treatment of Complicated Intra-abdominal Infections in Adults 
Authors
 조용균  ;  이정남  ;  서성옥  ;  김선회  ;  장진영  ;  김상걸  ;  윤영국  ;  이우정  ;  김민자 
Citation
 INFECTION AND CHEMOTHERAPY (감염과 화학요법), Vol.37(6) : 330-336, 2005 
Journal Title
INFECTION AND CHEMOTHERAPY (감염과 화학요법)(감염과 화학요법)
ISSN
 1598-8112 
Issue Date
2005
MeSH
Ertapenem ; Clinical efficacy ; Safety ; Intraabdominal infection
Keywords
Ertapenem ; Clinical efficacy ; Safety ; Intraabdominal infection
Abstract
Background: Ertapenem, a novel beta-lactam agent with a wide range of activity, has a pharmacokinetic profile and antimicrobial spectrum that support its potential use as a once-a-day agent for the treatment of common mixed aerobic and anaerobic pathogens encountered in intraabdominal infections.

Materials & Methods: The prospective, randomized, controlled, open, and multicenter trial was conducted to compare the clinical efficacy and safety of ertapenem with ceftriaxone plus metronidazole as therapy before or following adequate surgical management of complicated intraabdominal infections.

Results: One hundred sixty-three patients were included in the modified intent-to-treat population, of which 134 were clinically evaluable. Patients with a wide range of infections were enrolled; perforated appendicitis or periappendiceal abscess were most common. As for the modified intent-to-treat groups, 71 of 72 (98.6%) patients treated with ertapenem and 73 of 80 (91.3%) treated with ceftriaxone/metronidazole showed favorable clinical response.

Conclusion: In this study, the efficacy of ertapenem was equivalent to ceftriaxone plus metronidazole in the treatment of complicated intraabdominal infections. Ertapenem was generally well tolerated and had a similar safety and tolerability profile compared to ceftriaxone plus metronidazole. The results of this trial suggest that ertapenem could be considered as a useful option that could eliminate the need for combination and/or multi-dosed antibiotic regimens for the empiric treatment of complicated intraabdominal infections.
Files in This Item:
T200501568.pdf Download
DOI
OAK-2005-06580
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Woo Jung(이우정) ORCID logo https://orcid.org/0000-0001-9273-261X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/149956
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links