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한국인의 궤양성 대장염 연관 대장암의 현황: 대한장연구학회 다기관 공동연구

Other Titles
 The Current Status of Ulcerative Colitis-associated Colorectal Cancer in Korea: A KASID Study 
 장동경  ;  김영호  ;  변정식  ;  양석균  ;  정용우  ;  한동수  ;  김상균  ;  김태일  ;  김원호  ;  진윤태  ;  은창수  ;  최황  ;  최규용  ;  송인성 
 Korean Journal of Gastroenterology, Vol.46(4) : 276-282, 2005 
Journal Title
Korean Journal of Gastroenterology(대한소화기학회지)
Issue Date
Adolescent ; Adult ; Aged ; Colitis, Ulcerative/complications* ; Colitis, Ulcerative/epidemiology ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/etiology* ; Female ; Humans ; Incidence ; Korea/epidemiology ; Male ; Middle Aged
Background/Aims: The number of patients with ulcerative colitis has steadily increased since the mid-1980s. As the risk of colon cancer increases with duration and extents, colitic cancers are expected to increase in number in Korea. We surveyed the current status of colitic cancers and provided the perspectives in Korea.

Methods: Korean Association for the Study of Intestinal Diseases (KASID) collected and descriptively analyzed a total of eleven cases of colitic cancers occurred between 1993 and 2003.

Results: The mean age at the diagnosis of colitic cancer was 49.3 years, and the mean duration of ulcerative colitis was 12.5 years. Of the diagnosed cases, 91% was associated with pancolitis, 28% had right colon cancers and 18.2% had multiple tumors. Colitic cancers diagnosed at Dukes’ stage D were 36.3%. Stages at diagnosis were lower in patients with good compliance. Up to 2003, cumulative incidence ratio of colitic cancer to ulcerative colitis was estimated to be 0.5%, which was much less than the overall prevalence of 3.7% in the Western countries. This incidence was also less than the expected cumulative incidence ratio of 0.9%, which was estimated by adopting the average results of meta-analysis in the Western world.

Conclusions: As the incidence of ulcerative colitis has not reached a plateau, and as the diagnosis of colitic caners are delayed in Korea, the cumulative incidence of colitic cancers might have appeared to be low. Geographic and racial factors, and the effect of preventive measures might have contributed to the lower incidence which remains to be proven. Since colitic cancers are expected to increase steeply in the near future in Korea, the importance of surveillance and prevention cannot be over-emphasized.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
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