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인슐린 치료 중인 비만하지 않은 성인 발병 당뇨병의 임상적 특징

Other Titles
 Clinical Characteristics of Non-obese, Adult-onset Diabetes Requiring Insulin Treatment 
Authors
 박세은  ;  심완섭  ;  도미영  ;  강은석  ;  이유미  ;  안철우  ;  임승길  ;  김경래  ;  이현철  ;  차봉수 
Citation
 Journal of Korean Diabetes Association (당뇨병), Vol.29(6) : 557-565, 2005 
Journal Title
 Journal of Korean Diabetes Association (당뇨병) 
ISSN
 1015-6461 
Issue Date
2005
Abstract
Background: The aim of this study is to clarify the clinical characteristics of non-obese, adult-onset diabetes requiring insulin treatment and to compare the different characteristics of the three groups categorized according to diabetes classification. Methods: Total 128 diabetic patients who were non-obese (BMI < 25kg/m2 ) and had been diagnosed with diabetes after 20 years old, requiring insulin treatment were enrolled in the study. We divided the patients into three groups : 56 patients with type 1, 37 with unclassifiable, and 35 with type 2 diabetes. The type of diabetes was assigned by comparing serum C-peptide concentration and clinical phenotypes. Results: Type 2 and unclassifiable diabetes had no differences in BMI, the interval to use insulin, daily insulin dose, the level of HDL cholesterol and the positive rate for GAD Ab, but type 1 diabetes didn‘t. However, type 1 diabetes and unclassifiable group was lower prevalence of microvascular complications than type 2 diabetes (retinopathy 38.2, 52.8, 84.8 % ; nephropathy 37.7, 36.7, 74.2 % ; neuropathy 36.7, 36.7, 72.7 %, P < 0.05). The prevalence of macrovascular complications was higher in the order of type 1, unclassifiable, and type 2 diabetes (11.1, 29.4, 72.7 %, respectively, all P < 0.05). Conclusion: The clinical characteristics were similar between unclassifiable and type 2 diabetes, but the prevalence of microvascular complication in unclassifiable group had no significant difference compared with type 1 diabetes. The prevalence of macrovascular complications was significantly higher in the order of type 1, unclassifiable, and type 2 diabetes.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
강은석(Kang, Eun Seok) ORCID logo https://orcid.org/0000-0002-0364-4675
김경래(Kim, Kyung Rae)
심완섭(Shim, Wan Sub)
안철우(Ahn, Chul Woo) ORCID logo https://orcid.org/0000-0003-3733-7486
이유미(Rhee, Yumie) ORCID logo https://orcid.org/0000-0003-4227-5638
이현철(Lee, Hyun Chul)
임승길(Lim, Sung Kil)
차봉수(Cha, Bong Soo) ORCID logo https://orcid.org/0000-0003-0542-2854
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/149945
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