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제2형 당뇨병의 발생에 있어 가족력과 비만의 연관성

Other Titles
 The Association of Family History of Diabetes and Obesity in the Development of Type 2 Diabetes 
 심완섭  ;  김혜진  ;  김수경  ;  한승진  ;  강은석  ;  이유미  ;  안철우  ;  임승길  ;  김경래  ;  이현철  ;  차봉수 
 Journal of Korean Diabetes Association (당뇨병), Vol.29(6) : 540-547, 2005 
Journal Title
 Journal of Korean Diabetes Association (당뇨병) 
Issue Date
obesity ; family history of diabetes ; development of diabetes ; insulin secretion ; insulin resistance
obesity ; family history of diabetes ; development of diabetes ; insulin secretion ; insulin resistance
Background: Type 2 diabetes is characterized by defects in both insulin secretion and insulin action. Type 2 diabetes has a strong genetic basis, and obesity is also known as a important risk factor for development of diabetes. The relative effects of obesity and family history of diabetes (FHx) to develop diabetes have not been well characterized. The aim of this study was to analyze the relative role of insulin resistance and insulin secretion in the newly diagnosed type 2 diabetic patients according to the presence of FHx and obesity. Method: We evaluated the presence of FHx, fasting and postprandial glucose, C-peptide and insulin in 219 newly diagnosed type 2 diabetic patients without the history of drug therapy from Jan. 2003 to Oct. 2004. Result: The mean age of patients was 54.7±10.2(yr) and the mean BMI was 25.5±3.0 kg/m2. The patients with FHx develop diabetes earlier than them without FHx. BMI, fasting glucose, postprandial glucose, fasting C-peptide and HOMAIR value were not different between groups. But postprandial C-peptide, fasting insulin, postprandial insulin and HOMA β-cell value were significantly lower in patient with FHx than in them without FHx. Interestingly, obese (BMI 25kg/m ≥ 2) patients with FHx developed diabetes earlier than nonobese (BMI<25kg/m2) patients with FHx. Conclusion: Obesity plays an important role in the determination of the earlier onset of diabetes in patients with FHx. Intentional prevention of obesity may be an important means to prevent, at least delay, the onset of diabetes in the subjects with FHx.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Kyung Rae(김경래)
Kim, Soo Kyung(김수경)
Kim, Hae Jin(김혜진)
Shim, Wan Sub(심완섭)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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