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감염심내막염 환자의 체외순환 중 일어난 헤파린 내성

Other Titles
 Heparin Resistance during Cardiopulmonary Bypass in Infective Endocarditis Patients 
Authors
 나성원  ;  남상범  ;  오영준  ;  이종화  ;  안소운  ;  곽영란 
Citation
 KOREAN JOURNAL OF ANESTHESIOLOGY, Vol.49(6) : 868-871, 2005 
Journal Title
 KOREAN JOURNAL OF ANESTHESIOLOGY 
ISSN
 2005-6419 
Issue Date
2005
MeSH
antithrombin III deficiency ; heparin resistance ; infective endocarditis
Keywords
antithrombin III deficiency ; heparin resistance ; infective endocarditis
Abstract
Appropriate anticoagulation is essential for safe cardiopulmonary bypass (CPB). Two patients with infective endocarditis were scheduled for valve replacement. After an intravenous heparin injection for the CPB, the increases in the activated clotting time (ACT) in both patients were less than expected. Subsequent additional heparin administration failed to maintain a sufficient ACT for the CPB, and antithrombin III (AT III) tests during the CPB revealed low activities in both patients. Heparin resistance, due to consumption of circulating AT III as a result of infective endocarditis or prior heparinization, was postulated. While fresh frozen plasma (FFP) could not be timely administered in the first patient, ACT was successfully prolonged after the administration of FFP in the second. It is strongly suggested that adequate management of heparin resistance should be prepared for patients with infective endocarditis who require CPB.
Files in This Item:
T200501658.pdf Download
DOI
OAK-2005-06757
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Na, Sungwon(나성원) ORCID logo https://orcid.org/0000-0002-1170-8042
Nam, Sang Beom(남상범) ORCID logo https://orcid.org/0000-0002-9704-1866
Oh, Young Jun(오영준) ORCID logo https://orcid.org/0000-0002-6258-5695
Lee, Jong Wha(이종화)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/149892
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