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Increased 18F-FDG uptake on PET/CT is associated with poor arterial and portal perfusion on multiphase CT in patient with hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | 황상현 | - |
dc.date.accessioned | 2017-07-11T16:10:29Z | - |
dc.date.available | 2017-07-11T16:10:29Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/149200 | - |
dc.description | Dept. of Medicine/석사 | - |
dc.description.abstract | Purpose: To correlate 18F-FDG uptake on PET/CT with patterns of arterial and portal perfusion on multi-detector CT (MDCT) in patients with hepatocellular carcinoma (HCC) and to assess the value of variables from PET/CT and MDCT in predicting histological grades and overall survival. Methods: We retrospectively analyzed MDCT and PET/CT of 66 patients with HCC who underwent surgical treatment. Tumor peak standard uptake value (SUV) was divided by the mean liver SUV (T/LSUV). The mean tumor Hounsfield unit (HU) to mean liver HU was calculated for arterial (T/LHU-A) and portal phases (T/LHU-P). All patients were divided into three groups: I, T/LHU-A l and T/LHU-P <1; II, T/LHU-A >1 and T/LHU-P <1; and III, T/LHU-A >1 and T/LHU-P 1. The relationships between the CT perfusion groups and T/LSUV were assessed. Multivariate logistic regression analyses were performed using clinical and imaging parameters for predicting histological grade. Overall survival curves stratified by T/LSUV and CT perfusion groups were estimated using the Kaplan-Meier method. Results: Statistically significant differences in T/LSUV were noted between groups I and II (2.29 [range 1.74-3.60] vs. 1.20 [range 1.07-1.58], p<0.001) and groups I and III (2.29 [range 1.74-3.60] vs. 1.30 [range 1.07-1.43], P<0.001). In multivariate analysis, a T/LSUV cut-off of >1.46 was the only independent predictor of tumor grade, with an odds ratio of 8.462 (95% confidence interval 1.799-39.803). Kaplan-Meier curves showed significant differences in OS according to T/LSUV >1.62, group I perfusion pattern, and T/LSUV >1.62 plus group I perfusion pattern (P=0.04, P=0.021, and P=0.002, respectively). Conclusion: 18F-FDG PET/CT is not commonly used for detecting HCC due to its limited sensitivity. We found that increased 18F-FDG uptake is associated with decreased arterial and portal perfusion on MDCT. This can be used to preselect patients who would benefit the most from PET/CT. Meanwhile, 18F-FDG uptake remained as the only independent predictor of histological grade, and higher 18F-FDG uptake and lower perfusion pattern on MDCT were significantly related to shorter OS. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Increased 18F-FDG uptake on PET/CT is associated with poor arterial and portal perfusion on multiphase CT in patient with hepatocellular carcinoma | - |
dc.title.alternative | 간세포암에서 다중 컴퓨터단층촬영의 동맥, 정맥기에 조영되는 정도와 FDG 섭취 정도와 관련이 있음을 연구함 | - |
dc.type | Thesis | - |
dc.contributor.alternativeName | Hwang, Sang Hyun | - |
dc.type.local | Thesis | - |
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