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Bone regenerative efficacy of biphasic calcium phosphate collagen composite as a carrier of rhBMP
DC Field | Value | Language |
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dc.contributor.author | 이은웅 | - |
dc.date.accessioned | 2017-07-11T16:10:19Z | - |
dc.date.available | 2017-07-11T16:10:19Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/149117 | - |
dc.description | Dept. of Dentistry/박사 | - |
dc.description.abstract | Objective: This study compared the bone regenerative effects of a recombinant human bone morphogenetic protein 2 (rhBMP-2)-loaded collagen-based biphasic calcium phosphate composite (BCPC) and rhBMP-2-loaded biphasic calcium phosphate (BCP). Materials and methods: The in vitro release profiles of rhBMP-2-loaded BCP and BCPC were measured. The animal surgery was performed on ten rabbits. Four 8-mm-diameter circular calvarial defects were made and filled with BCP, BCPC, rhBMP-2-loaded BCP (BMP + BCP) and rhBMP-2-loaded BCPC (BMP + BCPC). The animals were euthanized either 2 or 8 weeks after surgery. Results: The initial burst release of rhBMP-2 was greater for BCP than for BCPC, and both presented a slow release pattern thereafter. In rabbit calvarial defects, the space maintaining capability and graft resorption of all experimental groups did not show statistical differences at 2 and 8 weeks. New bone formation in the rhBMP-2-loaded groups was greater than in the non-loaded groups at both weeks, but the amount of new bone was comparable between both rhBMP-2-loaded groups at both weeks. There was a distinct histologic difference between the BMP + BCP and BMP + BCPC groups at 2 weeks; the new bone formation occurred more in the intergranular spaces and the BCP-to-bone contact was greater in the BMP + BCPC group, but these differences were no longer discernible at 8 weeks. Conclusion: rhBMP-2 loaded BCP and BCPC significantly improved bone regeneration and BCPC led to a dense network of new bone and bone particles during the early healing period. BCPC can therefore be considered as a promising candidate for carrying rhBMP-2. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Bone regenerative efficacy of biphasic calcium phosphate collagen composite as a carrier of rhBMP | - |
dc.title.alternative | 2골형성 단백질 운반체로서 이상인산칼슘 콜라겐 복합체의 골재생 효과 | - |
dc.type | Thesis | - |
dc.contributor.alternativeName | Lee, Eun-Ung | - |
dc.type.local | Dissertation | - |
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