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아토피피부염 환아에서 혈청 TARC(Thymus and Activation-Regulated Chemokine)의 증가

Other Titles
 Increased Serum Thymus and Activation-regulated Chemokine (TARC) Levels in Children with Atopic Dermatitis 
Authors
 송태원  ;  권병철  ;  최성연  ;  신윤호  ;  이경은  ;  양혜선  ;  김경원  ;  김은수  ;  손명현  ;  김규언 
Citation
 Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지), Vol.15(3) : 250-256, 2005 
Journal Title
 Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지) 
ISSN
 1225-679X 
Issue Date
2005
MeSH
Atopic dermatitis ; Thymus and activation-regulated chemokine ; chemokine ; Scoring atopic dermatitis ; IgE mediated atopic dermatitis ; Non-IgE mediated atopic dermatitis
Keywords
Atopic dermatitis ; Thymus and activation-regulated chemokine ; chemokine ; Scoring atopic dermatitis ; IgE mediated atopic dermatitis ; Non-IgE mediated atopic dermatitis
Abstract
Purpose: Thymus and activation-regulated chemokine(TARC) is responsible for the trafficking of Th2 lymphocytes into sites of allergic inflammation. We tested whether TARC is a useful marker for childhood atopic dermatitis(AD) and we evaluated age-related differences in the level of TARC. Methods: Serum TARC level, serum total IgE level, total eosinophil count and specific IgE level were measured in 401 children. They were characterized as having IgE-mediated atopic dermatitis(n=157), non-IgE mediated atopic dermatitis(n=107), or as healthy control subjects(n=137). Results: TARC levels in AD significantly were higher than those in healthy control subjects.(152.9+/-11.6 vs 56.7+/-5.2 pg/mL, P<0.05) Serum TARC levels significantly correlated with disease severity(SCORAD index) both in children with IgE mediated AD(r=0.670, P<0.05) and children with non-IgE mediated AD.(r=0.605, P<0.05) Serum TARC levels in control subjects decreased in accordance with age.(r=-0.201, P<0.05) Conclusion: Serum TARC might be a useful marker for disease severity both in children with IgE mediated AD and children with non-IgE mediated AD. Serum TARC levels in control subjects decreased in accordance with ages.
Files in This Item:
T200500465.pdf Download
DOI
OAK-2005-03491
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Kyu Earn(김규언)
Kim, Eun Soo(김은수)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Song, Tae Won(송태원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147682
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