Cited 11 times in
Intraocular Properties of Hexadecyloxypropyl-Cyclic-Cidofovir in Guinea Pigs
DC Field | Value | Language |
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dc.contributor.author | 고형준 | - |
dc.date.accessioned | 2017-05-04T07:37:16Z | - |
dc.date.available | 2017-05-04T07:37:16Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1080-7683 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147549 | - |
dc.description.abstract | Objective: We previously reported a long-lasting crystalline lipid pro-drug of cyclic cidofovir, hexadecyloxypropyl–cyclic-cidofovir (HDP-cCDV), to treat experimental retinitis in rabbit eyes. With HDP-cCDV there was a longer intraocular therapeutic effect than with cidofovir (CDV) and no toxicity with 100 µg/eye. It has been known that CDV and related analogues lower intraocular pressure (IOP) after local use, and it is also accepted that the guinea pig is a better model to study this toxicity before human clinical trials. Methods: HDP-cCDV was intravitreally injected into 10 guinea pig eyes in doses of 4, 9, and 18 µg in 20 µL/eye. An 18-µg quantity is the dose equivalent to 100 µg/eye in the rabbit. Only one eye of each animal received drug and the fellow eye served as the control. After injection, the eyes were monitored with tonometry, ophthalmoscopy, electroretinography (ERG), and histology. Results: Intravitreal injections of doses of 18 µg/eye or lower revealed no toxicity and a high therapeutic index (132,000 to 3300 times higher than the 50% effective concentration for human cytomegalovirus) during 10 weeks of observation. The crystalline drug depot was ophthalmoscopically visible in the inferior vitreous cavity for 5–10 weeks. There was no difference in IOP between the drug-injected and control eyes at any time points (P > 0.05) except for day 3 after drug injection (P = 0.0338). All eyes demonstrated a normal ERG waveform with no differences between the treated and the fellow control eyes (P = 0.85). Histology revealed normal morphology and structures of the retina and ciliary body in all eyes (with or without treatment). Conclusion: Crystalline HDP-cCDV may be a long-lasting and safer alternative to cidofovir to treat CMV retinitis without the retinal or ciliary body toxicity observed with CDV. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Association For Ocular Pharmacology And Therapeutics | - |
dc.relation.isPartOf | JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antiviral Agents/toxicity* | - |
dc.subject.MESH | Ciliary Body/drug effects* | - |
dc.subject.MESH | Ciliary Body/pathology | - |
dc.subject.MESH | Cytomegalovirus Retinitis/drug therapy | - |
dc.subject.MESH | Cytosine/analogs & derivatives* | - |
dc.subject.MESH | Cytosine/toxicity | - |
dc.subject.MESH | Delayed-Action Preparations | - |
dc.subject.MESH | Electroretinography | - |
dc.subject.MESH | Guinea Pigs | - |
dc.subject.MESH | Injections | - |
dc.subject.MESH | Intraocular Pressure/drug effects* | - |
dc.subject.MESH | Organophosphonates/toxicity* | - |
dc.subject.MESH | Retina/drug effects* | - |
dc.subject.MESH | Retina/pathology | - |
dc.subject.MESH | Vitreous Body/drug effects | - |
dc.subject.MESH | Vitreous Body/metabolism | - |
dc.title | Intraocular Properties of Hexadecyloxypropyl-Cyclic-Cidofovir in Guinea Pigs | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학교실) | - |
dc.contributor.googleauthor | Stephanie Lu | - |
dc.contributor.googleauthor | Lingyun Cheng | - |
dc.contributor.googleauthor | Karl Y. Hostetler | - |
dc.contributor.googleauthor | Hyoung Jun Koh | - |
dc.contributor.googleauthor | James R. Beadle | - |
dc.contributor.googleauthor | Marie C. Davidson | - |
dc.contributor.googleauthor | W.R. Freeman | - |
dc.identifier.doi | 10.1089/jop.2005.21.205 | - |
dc.contributor.localId | A00152 | - |
dc.relation.journalcode | J01654 | - |
dc.identifier.eissn | 1557-7732 | - |
dc.identifier.pmid | 15969637 | - |
dc.identifier.url | http://online.liebertpub.com/doi/abs/10.1089/jop.2005.21.205 | - |
dc.subject.keyword | 15969637 | - |
dc.contributor.alternativeName | Koh, Hyoung Jun | - |
dc.citation.volume | 21 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 205 | - |
dc.citation.endPage | 209 | - |
dc.identifier.bibliographicCitation | JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, Vol.21(3) : 205-209, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 40324 | - |
dc.type.rims | ART | - |
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