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Functional disconnection of the semantic networks in schizophrenia

Authors
 Jae-Jin Kim  ;  Jeong Ho Seok  ;  Hae-Jeong Park  ;  Dong Soo Lee  ;  Myung Chul Lee  ;  Jun Soo Kwon 
Citation
 NEUROREPORT, Vol.16(4) : 355-359, 2005 
Journal Title
 NEUROREPORT 
ISSN
 0959-4965 
Issue Date
2005
MeSH
Adult ; Cerebral Cortex/physiology* ; Female ; Humans ; Male ; Nerve Net/physiology* ; Photic Stimulation/methods* ; Positron-Emission Tomography/methods ; Psychomotor Performance/physiology* ; Schizophrenia/physiopathology*
Keywords
15729137
Abstract
Patients with schizophrenia exhibit deficits in semantic processing, which can form the basis of thought disorders. The objective of this study was to explore functional connectivity between the activated areas during semantic processing in schizophrenia. Twelve patients with schizophrenia and 12 healthy controls were studied with [15O]H2O positron-emission tomography during semantic judgment. The expected activation in the left inferior occipitotemporal cortex significantly correlated with several other regional activations in normal study participants, but with no other regional activations in patients with schizophrenia. This finding suggests that schizophrenia involves a disconnection of semantic networks. The resultant distortion in semantic processing may have an impact on thought disorders.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-200503150-00010&LSLINK=80&D=ovft
DOI
OAK-2005-02977
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
Seok, Jeong Ho(석정호) ORCID logo https://orcid.org/0000-0002-9402-7591
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147490
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