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Vancomycin-resistant Enterococcal Bacteremia in a Hematology Unit: Molecular Epidemiology and Analysis of Clinical Course

Authors
 Jin-Hong Yoo  ;  Dong-Gun Lee  ;  Su Mi Choi  ;  Jung-Hyun Choi  ;  Wan-Shik Shin  ;  Myungshin Kim  ;  Dongeun Yong  ;  Kyungwon Lee  ;  Woo-Sung Min  ;  Chun-Choo Kim 
Citation
 Journal of Korean Medical Science, Vol.20(2) : 169-176, 2005 
Journal Title
 Journal of Korean Medical Science 
ISSN
 1011-8934 
Issue Date
2005
Abstract
An increase in vancomycin-resistant enterococcal (VRE) bacteremia in hemato-oncological patients (n=19) in our institution from 2000 through 2001 led us to analyze the molecular epidemiologic patterns and clinical features unique to our cases. The pulsed field gel electrophoresis of the isolates revealed that the bacteremia was not originated from a single clone but rather showed endemic pattern of diverse clones with small clusters. A different DNA pattern of blood and stool isolates from one patient suggested exogenous rather than endogenous route of infection. Enterococcus faecium carrying vanA gene was the causative pathogen in all cases. Patients with VRE bacteremia showed similar clinical courses compared with those with vancomycin-susceptible enterococcal (VSE) bacteremia. Vancomycin resistance did not seem to be a poor prognostic factor because of similar mortality (5/8, 62.5%) noted in VSE bacteremia. Initial disease severity and neutropenic status may be major determinants of prognosis in patients with VRE bacteraemia.
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DOI
10.3346/jkms.2005.20.2.169
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
용동은(Yong, Dong Eun) ORCID logo https://orcid.org/0000-0002-1225-8477
이경원(Lee, Kyungwon) ORCID logo https://orcid.org/0000-0003-3788-2134
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147477
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