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당뇨 혈액투석 환자에서 혈관내피세포 기능이상에 영향을 미치는 인자

Other Titles
 Affecting Factors on Endothelial Dysfunction in Diabetic End Stage Renal Disease Patients on Hemodialysis 
Authors
 류동열  ;  최훈영  ;  강신욱  ;  최규헌  ;  이호영  ;  한대석  ;  강이화  ;  김영아  ;  오성진  ;  김범석  ;  신석균 
Citation
 Korean Journal of Nephrology (대한신장학회지), Vol.24(1) : 47-56, 2005 
Journal Title
Korean Journal of Nephrology(대한신장학회지)
ISSN
 1225-0015 
Issue Date
2005
MeSH
Endothelial Dysfunction ; Flow-mediated dilation ; Diabetic End Stage Renal Disease(ESRD) Patients ; Hemodialysis
Keywords
Endothelial Dysfunction ; Flow-mediated dilation ; Diabetic End Stage Renal Disease(ESRD) Patients ; Hemodialysis
Abstract
BACKGROUND: Non-traditional risk factors of cardiovascular disease such as endothelial dysfunction, inflammation and malnutrition may be significant contributors to the excessive cardiovascular mortality in end stage renal disease (ESRD) patients. This study was undertaken to evaluate endothelial function in diabetic ESRD patients on hemodialysis and correlation between endothelial dysfunction and clinical, biochemical parameters.
METHODS: Twenty eight stable diabetic ESRD patients (M: F=1.3: 1, average age: 60.1+/-1.0 yr) on hemodialysis were included. flow-mediated dilation (FMD) of brachial artery was measured using Doppler ultrasonography with 10 MHz transducer. Subjective global assessment (SGA) was used to assess the nutritional status of patients.
RESULTS: The FMD (%) (% change of brachial artery diameter between before and after cuff inflation) was 5.1+/-1.0%. Serum albumin and C-reactive protein (CRP) were independent factors influencing SGA. When the patients were divided into groups according to history of ischemic heart disease (IHD), systolic pressure was significantly higher and FMD (%) was significantly lower in the group of patients with IHD compared with the group of patients without IHD. The FMD (%) showed significant positive correlation with SGA, serum albumin, and significant negative correlation with CRP. On multiple regression analysis, however, only CRP was an independent factor affecting FMD (%).
CONCLUSION: These findings suggest that CRP influenced the nutritional status of diabetic ESRD patients on hemodialysis, and endothelial dysfunction, estimated by FMD, was significantly correlated with CRP. Therefore, CRP can be a modifiable risk factor for endothelial dysfunction in diabetic ESRD patients on hemodialysis.
Files in This Item:
T200500196.pdf Download
DOI
OAK-2005-02874
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Ryu, Dong Ryeol(류동열)
Lee, Ho Yung(이호영)
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
Choi, Hoon Young(최훈영) ORCID logo https://orcid.org/0000-0002-4245-0339
Han, Dae Suk(한대석)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147450
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