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Investigation of a nosocomial outbreak of Acinetobacter baumannii producing PER-1 extended-spectrum β-lactamase in an intensive care unit

Authors
 S.H. Jeong  ;  I.K. Bae  ;  S.B. Kwon  ;  K. Lee  ;  D. Yong  ;  G.J. Woo  ;  J.H. Lee  ;  H.I. Jung  ;  S.J. Jang  ;  K.H. Sung  ;  S.H. Lee 
Citation
 Journal of Hospital Infection, Vol.59(3) : 242-248, 2005 
Journal Title
 Journal of Hospital Infection 
ISSN
 0195-6701 
Issue Date
2005
Abstract
We investigated an outbreak of Acinetobacter baumannii in an adult intensive care unit of Kosin University Gospel Hospital in Busan, Republic of Korea. The outbreak involved 10 cases of infection by A. baumannii producing PER-1 extended-spectrum β-lactamase over a seven-month period, and was caused by a single pulsed-field gel electrophoresis clone. The epidemic isolates were characterized by slight synergy between clavulanic acid and cefepime. Isoelectric focusing of crude bacterial extracts detected two nitrocefin-positive bands with pI values of 8.0 and 5.3. Polymerase chain reaction amplification and characterization of the amplicons by restriction analysis and direct sequencing indicated that the epidemic isolates carried a blaPER-1 determinant. The epidemic isolates were characterized by a multidrug-resistant phenotype that remained unchanged over the outbreak, including penicillins, β-lactam/β-lactamase inhibitor, extended-spectrum cephalosporins and monobactams. Isolation of infected patients and appropriate carbapenem therapy were successful in ending the outbreak. Our report indicates that the blaPER-1 resistance determinant may become an emerging therapeutic problem.
Full Text
http://www.sciencedirect.com/science/article/pii/S0195670104004220
DOI
10.1016/j.jhin.2004.09.025
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Bae, Il Kwon(배일권)
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147409
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