0 373

Cited 37 times in

How to predict HCC development in patients with chronic B viral liver disease?

Authors
 Han K.H.  ;  Ahn S.H. 
Citation
 INTERVIROLOGY, Vol.48(1) : 23-28, 2005 
Journal Title
INTERVIROLOGY
ISSN
 0300-5526 
Issue Date
2005
MeSH
Carcinoma, Hepatocellular/diagnosis* ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/epidemiology ; Disease Progression ; Early Diagnosis ; Female ; Hepatitis B, Chronic/complications* ; Hepatitis B, Chronic/pathology* ; Humans ; Korea ; Liver Neoplasms/diagnosis* ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/epidemiology ; Male ; Predictive Value of Tests ; Prospective Studies ; Risk Factors ; Ultrasonography
Keywords
Hepatitis B virus ; Hepatocellular carcinoma ; Risk factors
Abstract
Hepatocellular carcinoma (HCC) is one of the major malignant diseases in Asia. Although no randomized controlled studies have demonstrated decreased mortalities, screening for HCC has become an accepted procedure in the high-risk population. Since the incidence of HCC is strikingly different according to geographical distribution of risk factors, especially chronic hepatitis B virus (HBV) infection, a surveillance strategy in high endemic areas should be established according to national conditions. Chronic necro-inflammation by persistent HBV infection per se can progress to cirrhosis and the occurrence of HCC. As in other chronic liver diseases, the more risk factors the chronic B viral patients have, the higher occurrence of HCC was shown. Based on the risk factors of 4,339 Korean patients, the individual prediction model (IPM) was made by the calculation of relative weighs of risk factors and a self-exploited screening program for HCC was established accordingly. US screening at 6-month intervals was beneficial for the early detection of HCC, especially in the high-risk group, and prolonged survival. The usefulness of a tailored screening program with IPM for HCC was prospectively confirmed. The effective screening system for diagnosis of HCC limited to patients with chronic hepatitis B might be necessitated in high endemic area.
Full Text
http://www.karger.com/Article/FullText/82091
DOI
10.1159/000082091
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147395
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links