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저등급 표재성 방광암의 재발에서 Matrix Metalloproteinase 발현의 분석

DC FieldValueLanguage
dc.contributor.author강숙희-
dc.contributor.author양원재-
dc.contributor.author이미경-
dc.contributor.author조남훈-
dc.contributor.author최영득-
dc.date.accessioned2017-05-04T07:30:20Z-
dc.date.available2017-05-04T07:30:20Z-
dc.date.issued2005-
dc.identifier.issn0494-4747-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/147382-
dc.description.abstractPurpose: Superficial bladder transitional cell carcinomas (TCCa) have high recurrence rates following endoscopic resection. Most of the parameters used for the prediction of a recurrence are associated with high grade TCCa. However, there are few valid parameters for prediction of the recurrence of low grade TCCa. We aimed to elucidate the prime factor of a recurrence of superficial low grade bladder TCCa. Materials and Methods: Thirty cases of superficial low grade bladder TCCa were analyzed, 15 of which were recurred cases. Fresh frozen tumor and normal tissues were used for the analysis. Real-time reverse transcriptase polymerase chain reaction (RT-PCR) and Western blots analyses were subsequently performed to evaluate the validity of the molecules identified by a 0.12K cDNA array, including matrix metalloproteinase (MMP), oncogenes and cell-cycle-related genes. Results: On cDNA microarray analysis, MMP-1, 2, 9, 12 and 15, and transforming growth factor beta1 (TGFbeta1), vascular endothelial growth factor (VEGF) and fos were found to be significantly upregulated in the recurred cases. From the real-time RT-PCR for the validation of those molecules, MMP-1 and 12, and TGFbeta1, VEGF and fos were significantly overexpressed in the recurred cases. Western blot showed significant overexpression of MMP-1 and 12, and TGFbeta1, VEGF and fos in the recurred cases. Conclusions: The overexpressions of MMP-1 and 12, and TGFbeta1, VEGF and fos may be associated with the recurrence of superficial low grade bladder TCCa.-
dc.description.statementOfResponsibilityopen-
dc.format.extent327~335-
dc.languageKorean-
dc.publisher대한비뇨기과학회-
dc.relation.isPartOfKOREAN JOURNAL OF UROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBladder tumor-
dc.subject.MESHSuperficial-
dc.subject.MESHRecurrence-
dc.subject.MESHRT-PCR-
dc.subject.MESHMatrix metalloproteinases-
dc.title저등급 표재성 방광암의 재발에서 Matrix Metalloproteinase 발현의 분석-
dc.title.alternativeAnalysis of Matrix Metalloproteinase Expression in the Recurrence of Superficial Low Grade Urothelial Bladder Cancer-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentBioMedical Science Institute (의생명과학부)-
dc.contributor.departmentDept. of Urology (비뇨의학교실)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.departmentDept. of Urology (비뇨의학교실)-
dc.contributor.googleauthor최영득-
dc.contributor.googleauthor안현수-
dc.contributor.googleauthor조남훈-
dc.contributor.googleauthor이미경-
dc.contributor.googleauthor강숙희-
dc.contributor.googleauthor양원재-
dc.identifier.doiOAK-2005-02659-
dc.contributor.localIdA00044-
dc.contributor.localIdA02306-
dc.contributor.localIdA02769-
dc.contributor.localIdA03812-
dc.contributor.localIdA04111-
dc.relation.journalcodeJ02135-
dc.relation.journalsince1983~2009-
dc.relation.journalafter2009~ Korean Journal of Urology-
dc.subject.keywordBladder tumor-
dc.subject.keywordSuperficial-
dc.subject.keywordRecurrence-
dc.subject.keywordRT-PCR-
dc.subject.keywordMatrix metalloproteinases-
dc.contributor.alternativeNameKang, Suki-
dc.contributor.alternativeNameYang, Won Jae-
dc.contributor.alternativeNameLee, Mee Kyung-
dc.contributor.alternativeNameCho, Nam Hoon-
dc.contributor.alternativeNameChoi, Young Deuk-
dc.citation.volume46-
dc.citation.number4-
dc.citation.startPage327-
dc.citation.endPage335-
dc.identifier.bibliographicCitationKOREAN JOURNAL OF UROLOGY, Vol.46(4) : 327-335, 2005-
dc.date.modified2017-05-04-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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