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저등급 표재성 방광암의 재발에서 Matrix Metalloproteinase 발현의 분석
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강숙희 | - |
dc.contributor.author | 양원재 | - |
dc.contributor.author | 이미경 | - |
dc.contributor.author | 조남훈 | - |
dc.contributor.author | 최영득 | - |
dc.date.accessioned | 2017-05-04T07:30:20Z | - |
dc.date.available | 2017-05-04T07:30:20Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0494-4747 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147382 | - |
dc.description.abstract | Purpose: Superficial bladder transitional cell carcinomas (TCCa) have high recurrence rates following endoscopic resection. Most of the parameters used for the prediction of a recurrence are associated with high grade TCCa. However, there are few valid parameters for prediction of the recurrence of low grade TCCa. We aimed to elucidate the prime factor of a recurrence of superficial low grade bladder TCCa. Materials and Methods: Thirty cases of superficial low grade bladder TCCa were analyzed, 15 of which were recurred cases. Fresh frozen tumor and normal tissues were used for the analysis. Real-time reverse transcriptase polymerase chain reaction (RT-PCR) and Western blots analyses were subsequently performed to evaluate the validity of the molecules identified by a 0.12K cDNA array, including matrix metalloproteinase (MMP), oncogenes and cell-cycle-related genes. Results: On cDNA microarray analysis, MMP-1, 2, 9, 12 and 15, and transforming growth factor beta1 (TGFbeta1), vascular endothelial growth factor (VEGF) and fos were found to be significantly upregulated in the recurred cases. From the real-time RT-PCR for the validation of those molecules, MMP-1 and 12, and TGFbeta1, VEGF and fos were significantly overexpressed in the recurred cases. Western blot showed significant overexpression of MMP-1 and 12, and TGFbeta1, VEGF and fos in the recurred cases. Conclusions: The overexpressions of MMP-1 and 12, and TGFbeta1, VEGF and fos may be associated with the recurrence of superficial low grade bladder TCCa. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 327~335 | - |
dc.language | Korean | - |
dc.publisher | 대한비뇨기과학회 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF UROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Bladder tumor | - |
dc.subject.MESH | Superficial | - |
dc.subject.MESH | Recurrence | - |
dc.subject.MESH | RT-PCR | - |
dc.subject.MESH | Matrix metalloproteinases | - |
dc.title | 저등급 표재성 방광암의 재발에서 Matrix Metalloproteinase 발현의 분석 | - |
dc.title.alternative | Analysis of Matrix Metalloproteinase Expression in the Recurrence of Superficial Low Grade Urothelial Bladder Cancer | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | BioMedical Science Institute (의생명과학부) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | 최영득 | - |
dc.contributor.googleauthor | 안현수 | - |
dc.contributor.googleauthor | 조남훈 | - |
dc.contributor.googleauthor | 이미경 | - |
dc.contributor.googleauthor | 강숙희 | - |
dc.contributor.googleauthor | 양원재 | - |
dc.identifier.doi | OAK-2005-02659 | - |
dc.contributor.localId | A00044 | - |
dc.contributor.localId | A02306 | - |
dc.contributor.localId | A02769 | - |
dc.contributor.localId | A03812 | - |
dc.contributor.localId | A04111 | - |
dc.relation.journalcode | J02135 | - |
dc.relation.journalsince | 1983~2009 | - |
dc.relation.journalafter | 2009~ Korean Journal of Urology | - |
dc.subject.keyword | Bladder tumor | - |
dc.subject.keyword | Superficial | - |
dc.subject.keyword | Recurrence | - |
dc.subject.keyword | RT-PCR | - |
dc.subject.keyword | Matrix metalloproteinases | - |
dc.contributor.alternativeName | Kang, Suki | - |
dc.contributor.alternativeName | Yang, Won Jae | - |
dc.contributor.alternativeName | Lee, Mee Kyung | - |
dc.contributor.alternativeName | Cho, Nam Hoon | - |
dc.contributor.alternativeName | Choi, Young Deuk | - |
dc.citation.volume | 46 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 327 | - |
dc.citation.endPage | 335 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF UROLOGY, Vol.46(4) : 327-335, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 48554 | - |
dc.type.rims | ART | - |
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