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방광 이행상피세포암에 동반된 편평상피분화의 임상적 의미

Other Titles
 Clinical Significance of Squamous Differentiation in Bladder Transitional Cell Carcinoma 
Authors
 조강수  ;  양원재  ;  조남훈  ;  심효섭  ;  홍성준  ;  최영득 
Citation
 KOREAN JOURNAL OF UROLOGY, Vol.46(4) : 336-340, 2005 
Journal Title
KOREAN JOURNAL OF UROLOGY(대한비뇨기과학회지)
ISSN
 0494-4747 
Issue Date
2005
MeSH
Transitional cell carcinoma ; Bladder ; Neoplasms, squamous cell
Keywords
Transitional cell carcinoma ; Bladder ; Neoplasms, squamous cell
Abstract
Purpose: We evaluated the clinicopathological characteristics and clinical significance of squamous differentiation in bladder transitional cell carcinoma (TCCa).
Materials and Methods: Between 1993 and 2002, the medical records of 38 patients, who revealed squamous differentiation in bladder TCCa, were retrospectively analyzed with regard to their clinicopathological characteristics. The mean age and follow-up were 64.8 years (52-83) and 31.2 months (6-86), respectively.
Results: On cystoscopic examination, 68.4% (26 patients) were larger than 3cm in size, 63.2% (24 patients) non-papillary or mixed pattern and 68.4% (26 patients) multiple tumors comprised of more than 3. Histologically, the bladder TCCa, with squamous differentiation, were grade III in 89.5% (34 patients), and showed muscle proper invasion in 60.5% (23 patients). In a superficial bladder TCCa with squamous differentiation, the cancer tended to be multiple, more than 3 (80.0%), despite a size smaller than 3cm (66.7%). Of 15 patients with superficial cancer, recurrences were observed in 10 during follow-up, and in 7 (70.0%) revealing muscle proper invasion. The five-year recurrence and progression free survival were 23.9 and 36.9%, respectively. In invasive bladder TCCa with squamous differentiation, the cancer tended to have tumors larger than 3cm (91.3%). The five-year survival rate was 28.5% for invasive bladder cancer.
Conclusions: Squamous differentiation in bladder TCCa was associated with high grade and invasive bladder cancer. Superficial bladder TCCa with squamous differentiation tended to be multiple, and showed high recurrence and progression rates. Invasive bladder TCCa with squamous differentiation tended to be large and show a poor prognosis.
Files in This Item:
T200500123.pdf Download
DOI
OAK-2005-02654
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Shim, Hyo Sup(심효섭) ORCID logo https://orcid.org/0000-0002-5718-3624
Yang, Won Jae(양원재)
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
Hong, Sung Joon(홍성준) ORCID logo https://orcid.org/0000-0001-9869-065X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147381
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