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Therapeutic Effects of Holmium-166 Chitosan Complex in Rat Brain Tumor Model

 Ryoong Huh  ;  Yong Sook Park  ;  Jong Doo Lee  ;  Young Sun Chung  ;  Yong Gou Park  ;  Sang Sup Chung  ;  Jin Woo Chang 
 YONSEI MEDICAL JOURNAL, Vol.46(1) : 51-60, 2005 
Journal Title
Issue Date
Animals ; Brachytherapy ; Brain Neoplasms/diagnostic imaging* ; Brain Neoplasms/mortality ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Chitin/analogs & derivatives ; Chitin/pharmacology* ; Disease Models, Animal ; Glioma/diagnostic imaging* ; Glioma/mortality ; Glioma/pathology ; Holmium/pharmacology* ; Radioisotopes/pharmacology* ; Radionuclide Imaging ; Rats ; Rats, Wistar
Holmium-166 chitosan complex ; malignant glioma ; brachytherapy ; therapeutic effects
This study examined the effectiveness of Holmium-166 (Ho-166) chitosan complex therapy for a malignant glioma. Cultured C6 glioma cells (100,000 in 5 µl) were injected into the caudate/putamen of 200 - 250 gram Wistar rats. Five days later, a Ho-166 chitosan complex was injected into the same site of the glioma injection. Four injection doses were administered: the control group received PBS 10 µl, group 1 received an injection of 100 µCi (10 µl), group 2 received an injection of 50 µCi (5 µl), and group 3 received an injection of 10 µCi (1 µl). The average tumor volume for each group was 1.385 mm3 for the control group, 0.036 mm3 for group 1, 0.104 mm3 for group 2, and 0.111 mm3 for group 3. Compared with the control group, the size of the tumors in groups 1, 2 and 3 was reduced by an average of 97.4%, 92.5% and 91.9%, respectively. The Kaplan-Meier survival curve of group 2 was the longest, followed by groups 3, group 1 and the control. The mean survival was 22.8, 59, 60, and 44.6 days for the control group and groups 3, 2 and 1, respectively. H-E staining revealed that group 2 yielded the best results in the destruction of the malignant glioma. TUNEL staining and immunohistochemical studies indicated apoptotic features. The Ho-166 chitosan complex proved to be effective in destroying the malignant glioma.
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Gou(박용구)
Lee, Jong Doo(이종두)
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
Chung, Sang Sup(정상섭)
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