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Correlation between inhalant allergen-specific IgE and pulmonary function in children with asthma

 Sung-Yon Choi  ;  Myung Hyun Sohn  ;  Hye-Yung Yum  ;  Byoung-Chul Kwon  ;  Kyu-Earn Kim 
 PEDIATRIC PULMONOLOGY, Vol.39(2) : 150-155, 2005 
Journal Title
Issue Date
Administration, Inhalation ; Adolescent ; Allergens/administration & dosage* ; Asthma/diagnosis ; Asthma/immunology ; Asthma/physiopathology* ; Bronchial Provocation Tests ; Child ; Female ; Forced Expiratory Flow Rates/drug effects ; Forced Expiratory Flow Rates/physiology ; Humans ; Immunoglobulin E/administration & dosage* ; Korea ; Male ; Pulmonary Ventilation/drug effects ; Pulmonary Ventilation/physiology* ; Pyroglyphidae/immunology ; Retrospective Studies ; Severity of Illness Index ; Spirometry ; Vital Capacity/drug effects ; Vital Capacity/physiology
house dust mite ; asthma ; inhalant allergen ; pulmonary function test ; specific IgE
Sensitization to aeroallergens is associated with diminished lung function in adults. Little has been studied on the relationship between the inhalant allergen-specific IgE and pulmonary function in asthmatic children. This study was focused on four major inhalant allergens found in Korea, including Dermatophagoides pteronyssinus (Der p.), Dermatophagoides farinae (Der f.), and Alternaria- and German cockroach-specific IgEs, with evaluation of pulmonary function in relation to the amount of allergens. The parents or legal guardians of participants enrolled in this study gave informed consent. Fifty-five asthmatic patients and 48 nonasthmatic children were included. The amounts of specific IgE for the four specified inhalant allergens were determined by employing the CAP system FEIA. Forced expiratory volume in 1 sec (FEV1)/forced vital capacity (FVC), FEV1, and forced expiratory flow between 25% and 75% of FVC (FEF25–75) of subjects were evaluated through pulmonary function tests. In the asthmatic group, FEV1, FEV1/FVC, and FEF25–75 were significantly reduced (P < 0.05): reduction in FEV1 (r = −0.44) and FEF25–75 (r = −0.33) in association with the Der f.-specific allergen, and reduction in FEV1 (r = −0.37) and FEF25–75 (r = −0.34) in association with the Der p.-specific allergen, were observed. However, there was no significant correlation with German cockroach and Alternaria allergen. In the control group, no significant correlation was detectable between the allergen-specific IgE titers and the results of pulmonary function tests. In asthmatic patients, Der p.- and Der f.-specific IgEs, and not German cockroach and Alternaria, seem to play a considerable role in reduced pulmonary function among asthmatic children.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Byoung Chul(권병철)
Kim, Kyu Earn(김규언)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Choi, Sung Yon(최성연)
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