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The abnormalities of carbohydrate metabolism in Turner syndrome: Analysis of risk factors associated with impaired glucose tolerance

Authors
 In Kyoung Choi  ;  Duk Hee Kim  ;  Ho-Seong Kim 
Citation
 EUROPEAN JOURNAL OF PEDIATRICS, Vol.164(7) : 442-447, 2005 
Journal Title
 EUROPEAN JOURNAL OF PEDIATRICS 
ISSN
 0340-6199 
Issue Date
2005
MeSH
Adolescent ; Adult ; C-Peptide/blood ; Child ; Child, Preschool ; Comorbidity ; Glucose/analysis ; Glucose Intolerance/epidemiology* ; Glucose Tolerance Test ; Homeostasis ; Humans ; Insulin/blood ; Proinsulin/blood ; Risk Factors ; Turner Syndrome/epidemiology* ; Turner Syndrome/metabolism*
Keywords
Homeostasis model assessment ; Impaired glucose tolerance ; Oral glucose tolerance test ; Quantitative insulin sensitivity check index ; Turner syndrome
Abstract
An oral glucose tolerance test (OGTT) was performed in 103 patients with Turner syndrome (TS) who had normal fasting and postprandial glucose levels. The plasma glucose, insulin, C-peptide and proinsulin levels were measured every 30 min during the test. Using a homeostatic model assessment (HOMA) and a quantitative insulin sensitivity check index (QUICKI), the insulin resistance in TS patients was investigated. Diabetes mellitus and impaired glucose tolerance (IGT) were newly diagnosed in two and 18 patients respectively. There was a significant increase in mean plasma glucose, insulin, C-peptide and proinsulin reponse during an OGTT in the IGT group in contrast to the normal glucose tolerance (NGT) group ( P <0.05). There was a significant decrease in the quantitative insulin sensitivity check index (QUICKI) in the IGT group in contrast to the NGT group ( P <0.05). The fasting insulin and triglyceride levels strongly predicted the 2 h glucose level during the OGTT ( P <0.05). Conclusion:The oral glucose tolerance test is superior to the fasting and postprandial plasma glucose test for the early detection of abnormalities of carbohydrate metabolism in patients with Turner syndrome.
Full Text
http://link.springer.com/article/10.1007%2Fs00431-005-1643-x
DOI
10.1007/s00431-005-1643-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Duk Hee(김덕희)
Kim, Ho Seong(김호성) ORCID logo https://orcid.org/0000-0003-1135-099X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147300
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