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Gamma knife surgery for multiple hemangioblastomas

Authors
 Yong Sook Park  ;  Jong Hee Chang  ;  Jin Woo Chang  ;  Sang Sup Chung  ;  Yong Gou Park 
Citation
 JOURNAL OF NEUROSURGERY, Vol.102(Suppl.) : 97-101, 2005 
Journal Title
JOURNAL OF NEUROSURGERY
ISSN
 0022-3085 
Issue Date
2005
MeSH
Adult ; Aged ; Brain Neoplasms/pathology ; Brain Neoplasms/surgery* ; Diagnosis, Differential ; Female ; Follow-Up Studies ; Hemangioblastoma/pathology ; Hemangioblastoma/surgery* ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Radiation Dosage ; Radiosurgery/instrumentation* ; von Hippel-Lindau Disease/diagnosis ; von Hippel-Lindau Disease/surgery
Keywords
15662788
Abstract
OBJECT: The authors describe their experience in treating patients with hemangioblastoma, especially multiple lesions, with gamma knife surgery (GKS).
METHODS: Nine patients with 84 hemangioblastomas underwent GKS between July 1992 and May 2003. Three patients harbored a single lesion and six patients had multiple lesions. Of the six patients with multifocal tumors, a diagnosis of von Hippel-Lindau disease had been established in five. In the patients with multiple lesions, the mean radiation dose delivered to the tumor margin was 16.6 Gy (range 12.8-29.75 Gy). The mean margin isodose was 60% (range 40-95%). Three of the 84 lesions failed to be controlled after a mean follow-up period of 4.3 years (range 8.6-141 months). One patient who had undergone two GKS treatments suffered delayed radiation-induced complications, and posterior fossa decompression and ventriculoperitoneal shunt insertion were required.
CONCLUSIONS: To achieve tumor control and avoid morbidity, the surgeon should keep in mind minimizing field overlapping by using a small-diameter collimator or applying a steep dose gradient, and by accurate dose prescription.
Full Text
http://thejns.org/doi/abs/10.3171/sup.2005.102.s_supplement.0097
DOI
OAK-2005-02394
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Gou(박용구)
Park, Yong Sook(박용숙)
Chang, Jong Hee(장종희) ORCID logo https://orcid.org/0000-0003-1509-9800
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
Chung, Sang Sup(정상섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147298
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