Cited 85 times in

Correlation of KIT and platelet-derived growth factor receptor α mutations with gene activation and expression profiles in gastrointestinal stromal tumors

DC Field Value Language
dc.contributor.author강현주-
dc.contributor.author김주항-
dc.contributor.author김현기-
dc.contributor.author김혜령-
dc.contributor.author김호근-
dc.contributor.author노성훈-
dc.contributor.author윤채옥-
dc.contributor.author이환석-
dc.contributor.author형우진-
dc.date.accessioned2017-05-04T07:25:30Z-
dc.date.available2017-05-04T07:25:30Z-
dc.date.issued2005-
dc.identifier.issn0950-9232-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/147272-
dc.description.abstractActivating mutations of KIT and platelet-derived growth factor receptor alpha (PDGFRA) are known to be alternative and mutually exclusive genetic events in the development of gastrointestinal stromal tumors (GISTs). We examined the effect of the mutations of these two genes on the gene expression profile of 22 GISTs using the oligonucleotide microarray. Mutations of KIT and PDGFRA were found in 17 cases and three cases, respectively. The remaining two cases had no detectable mutations in either gene. The mutation status of KIT and PDGFRA was directly related to the expression levels of activated KIT and PDGFRA, and was also related to the different expression levels of activated proteins that play key roles in the downstream of the receptor tyrosine kinase III family. To evaluate the impact of mutation status and the importance of the type of mutation in gene expression and clinical features, microarray-derived data from 22 GISTs were interpreted using a principal component analysis (PCA). Three relevant principal component representing mutation of KIT, PDGFRA and chromosome 14q deletion were identified from the interpretation of the oligonucleotide microarray data with PCA. After supervised analysis, there was at least a two fold difference in expression between GISTs with KIT and PDGFRA mutation in 70 genes. Our findings demonstrate that mutations of KIT and PDGFRA affect differential activation and expression of some genes, and can be used for the molecular classification of GISTs.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfONCOGENE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHChromosomes, Human, Pair 14/genetics-
dc.subject.MESHDNA Mutational Analysis-
dc.subject.MESHFemale-
dc.subject.MESHGastrointestinal Stromal Tumors/genetics*-
dc.subject.MESHGastrointestinal Stromal Tumors/pathology-
dc.subject.MESHGene Expression Profiling-
dc.subject.MESHGene Expression Regulation, Neoplastic*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOligonucleotide Array Sequence Analysis-
dc.subject.MESHPlatelet-Derived Growth Factor/genetics*-
dc.subject.MESHPrincipal Component Analysis-
dc.subject.MESHProto-Oncogene Proteins c-kit/genetics*-
dc.subject.MESHStomach Neoplasms/genetics*-
dc.subject.MESHStomach Neoplasms/pathology-
dc.subject.MESHTranscriptional Activation-
dc.titleCorrelation of KIT and platelet-derived growth factor receptor α mutations with gene activation and expression profiles in gastrointestinal stromal tumors-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeResearch Institutes (연구소)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.departmentInstitute for Cancer Research (암연구소)-
dc.contributor.departmentDept. of Clinical Genetics (임상유전학과)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorHyun Ju Kang-
dc.contributor.googleauthorSuk Woo Nam-
dc.contributor.googleauthorHyunki Kim-
dc.contributor.googleauthorHwanseok Rhee-
dc.contributor.googleauthorNam-Gyun Kim-
dc.contributor.googleauthorHaeryoung Kim-
dc.contributor.googleauthorWoo Jin Hyung-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorJoo-Hang Kim-
dc.contributor.googleauthorChae-Ok Yun-
dc.contributor.googleauthorEdison T Liu-
dc.contributor.googleauthorHoguen Kim-
dc.identifier.doi10.1038/sj.onc.1208358-
dc.contributor.localIdA00092-
dc.contributor.localIdA00945-
dc.contributor.localIdA01108-
dc.contributor.localIdA01168-
dc.contributor.localIdA01183-
dc.contributor.localIdA01281-
dc.contributor.localIdA02614-
dc.contributor.localIdA03334-
dc.contributor.localIdA04382-
dc.relation.journalcodeJ02413-
dc.identifier.eissn1476-5594-
dc.identifier.pmid15690055-
dc.identifier.urlhttp://www.nature.com/onc/journal/v24/n6/full/1208358a.html-
dc.subject.keyword15690055-
dc.contributor.alternativeNameKang, Hyun Ju-
dc.contributor.alternativeNameKim, Joo Hang-
dc.contributor.alternativeNameKim, Hyun Ki-
dc.contributor.alternativeNameKim, Hae Ryoung-
dc.contributor.alternativeNameKim, Ho Keun-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameYun, Chae Ok-
dc.contributor.alternativeNameRhee, Hwan Seok-
dc.contributor.alternativeNameHyung, Woo Jin-
dc.citation.volume24-
dc.citation.number6-
dc.citation.startPage1066-
dc.citation.endPage1074-
dc.identifier.bibliographicCitationONCOGENE, Vol.24(6) : 1066-1074, 2005-
dc.date.modified2017-05-04-
dc.identifier.rimsid48446-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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