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RET/PTC and CK19 expression in papillary thyroid carcinoma and its clinicopathologic correlation

Authors
 Eunah Shin  ;  Woung Youn Chung  ;  Woo Ick Yang  ;  Cheong Soo Park  ;  Soon Won Hong 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.20(1) : 98-104, 2005 
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
 1011-8934 
Issue Date
2005
MeSH
Adenocarcinoma, Papillary/metabolism* ; Adult ; Carcinoma/pathology ; Cell Line, Tumor ; Cytoplasm/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Keratins/biosynthesis* ; Korea ; Lymphatic Metastasis ; Male ; Middle Aged ; Oligonucleotide Array Sequence Analysis ; Oncogene Proteins/biosynthesis* ; Proto-Oncogene Proteins c-ret ; Receptor Protein-Tyrosine Kinases/biosynthesis* ; Thyroid Neoplasms/metabolism* ; Thyroid Neoplasms/pathology
Keywords
Thyroid Neoplasms ; Proto-oncogene Proteins Ret ; Keratin ; Korea ; Immunohistochemistry ; Protein Array Analysis
Abstract
Recently, the rearrangement of RET proto-oncogene has been reported to be the most common genetic change in papillary thyroid carcinoma (PTC). However, its prevalence has been reported variably and its relation to clinical outcome has been controversial. The characteristic nuclear features of PTC usually render the diagnosis, but problem arises with equivocal cytologic features that are present focally. Although there remains some controversy, CK19 has been reported to be a useful ancillary tool for diagnosis of PTC. To evaluate the expression rate of RET/PTC rearrangement and CK19 in PTCs in a Korean population, we studied 115 papillary thyroid carcinomas in 3 mm-core tissue microarray based immunohistochemical analysis. The prevalence of Ret protein expression was 62.6% and the CK19 immunoreactivity was 80.9%. There was no statistically significant association between the Ret positivity and CK19 immunoreactivity, although the percent agreement of the two was relatively high. The clinicopathological variables did not correlate with the expression of Ret. In conclusion, the prevalence of Ret protein expression and its clinicopathological implications in a Korean population are not much different from those reported in previous studies. However, its detection via immunohistochemistry can be a useful diagnostic tool for diagnosing papillary thyroid carcinoma in conjunction with CK19.
Files in This Item:
T200500010.pdf Download
DOI
10.3346/jkms.2005.20.1.98
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Cheong Soo(박정수)
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Chung, Woong Youn(정웅윤)
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147269
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