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Protective effect of etanercept, an inhibitor of tumor necrosis factor-α, in a rat model of retinal ischemia.

DC FieldValueLanguage
dc.contributor.author김찬윤-
dc.contributor.author홍사민-
dc.contributor.author배형원-
dc.contributor.author성공제-
dc.date.accessioned2017-02-27T08:28:07Z-
dc.date.available2017-02-27T08:28:07Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/147189-
dc.description.abstractBACKGROUND: To assess the neuroprotective effect of etanercept (Enbrel®) which is a commercialized Tumor necrosis factor-α (TNF-α) inhibitor on axonal injury in an animal model of acute ischemia. METHODS: Acute ischemia was induced by intraocular pressure elevation in 36 rats. The treatment groups underwent subcutaneous injection of etanercept (0.3 or 1.0 mg/kg) three times per week up to 4 weeks. The control groups were treated in the same manner using the same volume of phosphate-buffered saline (PBS). Optic nerve damage was evaluated by counting the number of axons under a transmission electron microscope. Microglial cell activity was assessed using Iba1 and CD68. RESULTS: After induction of ischemia, the ratio of preserved axons was significantly greater in the 2-week 1.0-mg/kg etanercept-treated group than in the PBS-treated group (p = 0.062). The 4-week 0.3-mg/kg and 1.0-mg/kg etanercept-treated groups also showed significantly higher ratios of preserved axons than did the PBS-treated group (p = 0.021 and 0.003, respectively). The expression of Iba1 and CD68 in the optic nerve was lower in the etanercept-treated groups than in the PBS-treated groups. Immunohistochemical staining using rabbit anti-Iba1 antibody showed that the amount of microglia at the optic nerve head was noticeably lower in the etanercept-treated groups than in the PBS-treated groups. CONCLUSIONS: Etanercept significantly suppressed optic nerve injury in this rat model of acute ischemia. This in vivo study suggests that etanercept might be a novel neuroprotective treatment agent for TNF-α-related disease.-
dc.description.statementOfResponsibilityopen-
dc.format.extent75-
dc.publisherBioMed Central-
dc.relation.isPartOfBMC OPHTHALMOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBlotting, Western-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHEtanercept/therapeutic use*-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHIschemia/drug therapy*-
dc.subject.MESHIschemia/etiology-
dc.subject.MESHMale-
dc.subject.MESHNeuroprotective Agents/therapeutic use*-
dc.subject.MESHOptic Nerve Diseases/drug therapy*-
dc.subject.MESHOptic Nerve Diseases/etiology-
dc.subject.MESHOptic Nerve Diseases/pathology-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHRetinal Diseases/drug therapy*-
dc.subject.MESHRetinal Diseases/pathology-
dc.subject.MESHRetinal Ganglion Cells/drug effects-
dc.subject.MESHRetinal Ganglion Cells/pathology-
dc.subject.MESHTumor Necrosis Factor-alpha/antagonists & inhibitors-
dc.titleProtective effect of etanercept, an inhibitor of tumor necrosis factor-α, in a rat model of retinal ischemia.-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Ophthalmology-
dc.contributor.googleauthorHyoung Won Bae-
dc.contributor.googleauthorNaeun Lee-
dc.contributor.googleauthorGong Je Seong-
dc.contributor.googleauthorSeungsoo Rho-
dc.contributor.googleauthorSamin Hong-
dc.contributor.googleauthorChan Yun Kim-
dc.identifier.doi10.1186/s12886-016-0262-9-
dc.contributor.localIdA01035-
dc.contributor.localIdA04395-
dc.contributor.localIdA01814-
dc.contributor.localIdA01946-
dc.relation.journalcodeJ00370-
dc.identifier.eissn1471-2415-
dc.relation.journalsince2001~-
dc.identifier.pmid27259948-
dc.subject.keywordAcute ischemia-
dc.subject.keywordAxonal injury-
dc.subject.keywordEtanercept-
dc.subject.keywordMicroglia-
dc.subject.keywordTumor necrosis factor-α-
dc.contributor.alternativeNameKim, Chan Yun-
dc.contributor.alternativeNameHong, Sa Min-
dc.contributor.alternativeNameBae, Hyoung Won-
dc.contributor.alternativeNameSeong, Gong Je-
dc.contributor.affiliatedAuthorKim, Chan Yun-
dc.contributor.affiliatedAuthorHong, Sa Min-
dc.contributor.affiliatedAuthorBae, Hyoung Won-
dc.contributor.affiliatedAuthorSeong, Gong Je-
dc.citation.volume16-
dc.citation.startPage75-
dc.identifier.bibliographicCitationBMC OPHTHALMOLOGY, Vol.16 : 75, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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