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Activation of the polycomb repressive complex pathway in the bone marrow resident cells of diffuse large B-cell lymphoma patients.

Authors
 Eun Ji Oh  ;  Eun Kyung Kim  ;  Woo Ick Yang  ;  Sun Och Yoon 
Citation
 Leukemia & Lymphoma, Vol.57(8) : 1921-1932, 2016 
Journal Title
 Leukemia & Lymphoma 
ISSN
 1042-8194 
Issue Date
2016
MeSH
Adult ; Aged ; Biopsy ; Bone Marrow/pathology ; Bone Marrow Cells/metabolism* ; Cell Nucleus/metabolism ; Disease-Free Survival ; Enhancer of Zeste Homolog 2 Protein/metabolism* ; Female ; Histones/metabolism ; Humans ; Lymphoma, Large B-Cell, Diffuse/mortality ; Lymphoma, Large B-Cell, Diffuse/pathology* ; Male ; Methylation ; Middle Aged ; Polycomb Repressive Complex 2/metabolism* ; Prognosis ; Proto-Oncogene Proteins c-myc/metabolism ; Signal Transduction* ; Tumor Microenvironment*
Keywords
Bone marrow ; c-MYC ; diffuse ; histone H3 trimethylation at lysine 27 ; large B cell ; lymphoma ; polycomb repressive complex 2
Abstract
The present study investigated the activation of polycomb repressive complex 2 (PRC2) pathway proteins in the resident cells within the bone marrow hematopoietic microenvironment of diffuse large B-cell lymphoma (DLBCL) patients. PRC2 proteins (enhancer of zeste homolog 2, suppressor of zeste 12 homolog, and embryonic ectoderm development), histone methylation mark (H3K27me3), and c-MYC activation were evaluated in pretreatment bone marrow from 208 DLBLC patients. Positive expression of the PRC2, H3K27me3, and c-MYC in the bone marrow resident cells was more frequent in cases with bone marrow involvement of tumor. The expression among PRC2, H3K27me3 mark, and c-MYC was closely correlated. Positive PRC2 expression in bone marrow resident cells was significantly associated with inferior progression-free survival (PFS) and overall survival (OS) and determined to be an independent prognostic factor of inferior PFS and OS. In conclusion, the PRC pathway was frequently activated in bone marrow resident cells of DLBCL patients, and PRC activation was tumor-related and associated with poor clinical outcomes.
Full Text
http://www.tandfonline.com/doi/abs/10.3109/10428194.2015.1121261
DOI
10.3109/10428194.2015.1121261
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
김은경(Kim, Eun Kyung)
양우익(Yang, Woo Ick) ORCID logo https://orcid.org/0000-0002-6084-5019
오은지(Oh, Eun Ji)
윤선옥(Yoon, Sun Och) ORCID logo https://orcid.org/0000-0002-5115-1402
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147152
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