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Betahistine reduces postoperative nausea and vomiting after laparoscopic gynecological surgery.

Authors
 Jin S. CHO  ;  Eun J. KIM  ;  Jae H. LEE  ;  So Y. KIM  ;  Jeong M. KIM  ;  Jung I. BYUN  ;  Eun J. NAM  ;  Bon N. KOO 
Citation
 Minerva Anestesiologica, Vol.82(6) : 649-656, 2016 
Journal Title
 Minerva Anestesiologica 
ISSN
 0375-9393 
Issue Date
2016
Keywords
Betahistine ; Dizziness ; Gynecologic surgical procedures ; Laparoscopy ; Ondansetron ; Postoperative nausea and vomiting
Abstract
BACKGROUND: Patients undergoing laparoscopic gynecological surgery are at high risk of postoperative nausea and vomiting (PONV). We compared the antiemetic efficacy of ondansetron plus betahistine with that of ondansetron alone in this patient population. METHODS: In this randomized, double-blinded study, 168 patients were randomly allocated to receive placebo (O group) or betahistine 18 mg (OB group) orally 3 hours before surgery and 24 hours thereafter. In both groups, ondansetron 4 mg was administered at the end of surgery and 8 mg were added to an intravenous patient-controlled analgesia (IV-PCA) fentanyl solution. The primary outcome was complete response (no PONV and no rescue antiemetics) during the first 48 hours after surgery. The severity of nausea, pain score, and adverse events were assessed. RESULTS: The incidence of complete response was significantly higher in OB group than in O group (69% vs. 46%, P=0.004). The severity of nausea was lower in OB group than in O group during 30 minutes to 6 hours and 6 to 24 hours after surgery (P=0.001 and P<0.001). Pain score was similar between the groups. The incidence of dizziness was lower in OB group than in O group (13% vs. 40%, P < 0.001). Six patients (7%) in OB group and 15 patients (18%) in O group required early IV-PCA discontinuation, primarily because of PONV and/or dizziness (P=0.038). CONCLUSIONS: Compared to ondansetron alone, ondansetron plus betahistine was more effective to prevent PONV and dizziness in high-risk patients undergoing laparoscopic gynecological surgery.
Full Text
http://www.minervamedica.it/en/journals/minerva-anestesiologica/article.php?cod=R02Y2016N06A0649
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
구본녀(Koo, Bon-Nyeo) ORCID logo https://orcid.org/0000-0002-3189-1673
김소연(Kim, So Yeon) ORCID logo https://orcid.org/0000-0001-5352-157X
김은정(Kim, Eun Jung) ORCID logo https://orcid.org/0000-0002-5693-1336
김정민(Kim, Jeongmin) ORCID logo https://orcid.org/0000-0002-0468-8012
남은지(Nam, Eun Ji)
이재훈(Lee, Jae Hoon) ORCID logo https://orcid.org/0000-0001-6679-2782
조진선(Cho, Jin Sun) ORCID logo https://orcid.org/0000-0002-5408-4188
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147126
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