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Sox2 contributes to tooth development via Wnt signaling.

DC Field Value Language
dc.contributor.author정한성-
dc.contributor.author김은정-
dc.date.accessioned2017-02-27T08:06:45Z-
dc.date.available2017-02-27T08:06:45Z-
dc.date.issued2016-
dc.identifier.issn0302-766X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/147086-
dc.description.abstractThe transcription factor Sox2 is a stem cell marker that dictates cell lineage. It has been shown to mark the epithelial stem cells of the continuously growing mouse incisors. Sox2 also interferes with Wnt signaling by binding to β-catenin, a central mediator of the Wnt pathway. We show that these functions of Sox2 are essential for mouse molar development. Sox2 has previously been shown to play a role in the formation of new teeth from the existing dental epithelium. To assess Sox2 function related to cell migration within a tooth, we monitored cell movement by using a DiI system and observed that DiI moves from molar 1 to molar 2 during tooth development. However, upon temporal knockdown of Sox2, DiI remains in the molar 1 region. This study also provides novel insights into the role of Sox2 and the important validation of Sox2 as a potent target in Wnt signaling during tooth development. Our data reveal that the degradation of Wnt signaling caused by the knockdown of Sox2 results in a lack of cell migration during tooth development.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer-Verlag-
dc.relation.isPartOfCELL AND TISSUE RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCell Movement-
dc.subject.MESHGene Expression Regulation, Developmental-
dc.subject.MESHGene Knockdown Techniques-
dc.subject.MESHMice-
dc.subject.MESHRNA, Small Interfering/metabolism-
dc.subject.MESHSOXB1 Transcription Factors/metabolism*-
dc.subject.MESHTime Factors-
dc.subject.MESHTooth/embryology*-
dc.subject.MESHTooth/metabolism*-
dc.subject.MESHWnt Signaling Pathway*-
dc.titleSox2 contributes to tooth development via Wnt signaling.-
dc.typeArticle-
dc.publisher.locationGermany-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Oral Biology-
dc.contributor.googleauthorMin-Jung Lee-
dc.contributor.googleauthorEun-Jung Kim-
dc.contributor.googleauthorKeishi Otsu-
dc.contributor.googleauthorHidemitsu Harada-
dc.contributor.googleauthorHan-Sung Jung-
dc.identifier.doi10.1007/s00441-016-2363-4-
dc.contributor.localIdA03758-
dc.relation.journalcodeJ00474-
dc.identifier.eissn1432-0878-
dc.identifier.pmid26846112-
dc.identifier.urlhttp://link.springer.com/article/10.1007/s00441-016-2363-4-
dc.subject.keywordCell migration-
dc.subject.keywordDiI system-
dc.subject.keywordSox2-
dc.subject.keywordTooth-
dc.subject.keywordWnt signaling-
dc.contributor.alternativeNameJung, Han Sung-
dc.contributor.affiliatedAuthorJung, Han Sung-
dc.citation.volume365-
dc.citation.number1-
dc.citation.startPage77-
dc.citation.endPage84-
dc.identifier.bibliographicCitationCELL AND TISSUE RESEARCH, Vol.365(1) : 77-84, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid47118-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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