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Overview of IgG4-Related Tubulointerstitial Nephritis and Its Mimickers.

Authors
 Hyeon Joo Jeong  ;  Su-Jin Shin  ;  Beom Jin Lim 
Citation
 Journal of Pathology and Translational Medicine, Vol.50(1) : 26-36, 2016 
Journal Title
 Journal of Pathology and Translational Medicine 
ISSN
 2383-7837 
Issue Date
2016
Keywords
Anti-neutrophil cytoplasmic antibody-associated vasculitis ; Glomerulonephritis, membranous ; IgG4-related disease ; Lupus nephritis ; Sjögren’s syndrome
Abstract
Tubulointerstitial nephritis (TIN) is the most common form of renal involvement in IgG4-related disease. It is characterized by a dominant infiltrate of IgG4-positive plasma cells in the interstitium and storiform fibrosis. Demonstration of IgG4-positive plasma cells is essential for diagnosis, but the number of IgG4-positive cells and the ratio of IgG4-positive/IgG-positive plasma cells may vary from case to case and depending on the methods of tissue sampling even in the same case. IgG4-positive plasma cells can be seen in TIN associated with systemic lupus erythematosus, Sjögren syndrome, or anti-neutrophil cytoplasmic antibody-associated vasculitis, which further add diagnostic confusion and difficulties. To have a more clear view of IgG4-TIN and to delineate differential points from other TIN with IgG4-positive plasma cell infiltrates, clinical and histological features of IgG4-TIN and its mimickers were reviewed. In the rear part, cases suggesting overlap of IgG4-TIN and its mimickers and glomerulonephritis associated with IgG4-TIN were briefly described.
Files in This Item:
T201602043.pdf Download
DOI
10.4132/jptm.2015.11.09
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
신수진(Shin, Su Jin)
임범진(Lim, Beom Jin) ORCID logo https://orcid.org/0000-0003-2856-0133
정현주(Jeong, Hyeon Joo) ORCID logo https://orcid.org/0000-0002-9695-1227
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147067
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