Cited 9 times in
Elderly Patients Require Higher Doses of Sugammadex for Rapid Recovery from Deep Neuromuscular Block.
DC Field | Value | Language |
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dc.contributor.author | 김소연 | - |
dc.contributor.author | 신서경 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 전은경 | - |
dc.contributor.author | 한동우 | - |
dc.date.accessioned | 2017-02-27T08:01:01Z | - |
dc.date.available | 2017-02-27T08:01:01Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1742-7835 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147056 | - |
dc.description.abstract | This study compared the doses of sugammadex needed for rapid recovery from deep neuromuscular blockade (NMB) between young and elderly adults. Twenty-two young (20-40 yrs) and 22 elderly (≥70 yrs) adults were enrolled, and deep NMB of 1-2 post-tetanic counts was maintained with rocuronium intraoperatively. Predetermined doses of sugammadex were given at the end of surgery starting at 4.0 mg/kg for the first patient of each group. Doses were decreased or increased in following patients by 0.5 mg/kg, depending on the 'success' or 'failure' of rapid recovery in the preceding patient. 'Success' was defined as adequate recovery (train-of-four ratio 0.9) within 2 min. after sugammadex administration. The median (range) of ages was 29 (20-40) and 73 (70-84) yrs for the young and elderly adults, respectively. Doses of sugammadex facilitating adequate recovery from deep NMB within 2 min. in each patient population with 50% and 95% probability were defined as ED50 and ED95 , respectively. The ED50 estimated by the Dixon's method was significantly higher in the elderly compared to young adults [4.2 ± 0.4 mg/kg versus 3.3 ± 0.3 mg/kg, p < 0.001]. The ED50 (83% CI) estimated by isotonic regression was 4.5 (4.2-5.0) mg/kg in elderly adults and 3.3 (3.2-3.4) mg/kg in young adults. The ED95 (95% CI) estimated by isotonic regression was 5.4 (4.9-5.5) mg/kg and 4.4 (3.9-4.5) mg/kg in the elderly and young adults, respectively. In conclusion, dose adjustments of sugammadex should be considered when rapid recovery from deep NMB is needed in elderly adults. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 462~467 | - |
dc.publisher | Blackwell | - |
dc.relation.isPartOf | BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Age Factors | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Androstanols/administration & dosage* | - |
dc.subject.MESH | Anesthesia Recovery Period | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neuromuscular Blockade* | - |
dc.subject.MESH | Neuromuscular Nondepolarizing Agents/administration & dosage* | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Young Adult | - |
dc.subject.MESH | gamma-Cyclodextrins/administration & dosage | - |
dc.subject.MESH | gamma-Cyclodextrins/pharmacology* | - |
dc.title | Elderly Patients Require Higher Doses of Sugammadex for Rapid Recovery from Deep Neuromuscular Block. | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine | - |
dc.contributor.googleauthor | Seokyung Shin | - |
dc.contributor.googleauthor | Dong Woo Han | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Mi Kyung Song | - |
dc.contributor.googleauthor | Eun-kyung Jun | - |
dc.contributor.googleauthor | So Yeon Kim | - |
dc.identifier.doi | 10.1111/bcpt.12507 | - |
dc.contributor.localId | A00616 | - |
dc.contributor.localId | A02109 | - |
dc.contributor.localId | A03312 | - |
dc.contributor.localId | A04661 | - |
dc.contributor.localId | A04274 | - |
dc.relation.journalcode | J00271 | - |
dc.identifier.eissn | 1742-7843 | - |
dc.relation.journalsince | 2004~ | - |
dc.identifier.pmid | 26505986 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/bcpt.12507/abstract | - |
dc.relation.journalbefore | ~2003 Pharmacology & Toxicology | - |
dc.contributor.alternativeName | Kim, So Yeon | - |
dc.contributor.alternativeName | Shin, Seo Kyung | - |
dc.contributor.alternativeName | Lee, Hye Sun | - |
dc.contributor.alternativeName | Jun, Eun kyung | - |
dc.contributor.alternativeName | Han, Dong Woo | - |
dc.contributor.affiliatedAuthor | Kim, So Yeon | - |
dc.contributor.affiliatedAuthor | Shin, Seo Kyung | - |
dc.contributor.affiliatedAuthor | Lee, Hye Sun | - |
dc.contributor.affiliatedAuthor | Jun, Eun kyung | - |
dc.contributor.affiliatedAuthor | Han, Dong Woo | - |
dc.citation.volume | 118 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 462 | - |
dc.citation.endPage | 467 | - |
dc.identifier.bibliographicCitation | BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, Vol.118(6) : 462-467, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47088 | - |
dc.type.rims | ART | - |
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