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Early Changes in the Serotype Distribution of Invasive Pneumococcal Isolates from Children after the Introduction of Extended-valent Pneumococcal Conjugate Vaccines in Korea, 2011-2013.

 Eun Young Cho  ;  Eun Hwa Choi  ;  Jin Han Kang  ;  Kyung-Hyo Kim  ;  Dong Soo Kim  ;  Yae-Jean Kim  ;  Young Min Ahn  ;  Byung Wook Eun  ;  Sung Hee Oh  ;  Sung-Ho Cha  ;  Hye-Kyung Cho  ;  Young Jin Hong  ;  Kwang Nam Kim  ;  Nam Hee Kim  ;  Yun-Kyung Kim  ;  Jong-Hyun Kim  ;  Hyunju Lee  ;  Taekjin Lee  ;  Hwang Min Kim  ;  Kun Song Lee  ;  Chun Soo Kim  ;  Su Eun Park  ;  Young Mi Kim  ;  Chi Eun Oh  ;  Sang Hyuk Ma  ;  Dae Sun Jo  ;  Young Youn Choi  ;  Jina Lee  ;  Geun-Ryang Bae  ;  Ok Park  ;  Young-Joon Park  ;  Eun Seong Kim  ;  Hoan Jong Lee 
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.31(7) : 1082-1088, 2016 
Journal Title
Issue Date
Adolescent ; Bacteremia/complications ; Bacteremia/diagnosis ; Child ; Child, Preschool ; Female ; Hospitals ; Humans ; Infant ; Male ; Pneumococcal Infections/microbiology ; Pneumococcal Infections/prevention & control* ; Pneumococcal Vaccines/immunology* ; Republic of Korea ; Serotyping ; Streptococcus pneumoniae/classification* ; Streptococcus pneumoniae/isolation & purification ; Vaccines, Conjugate/immunology*
Pneumococcal Vaccines ; Serotype ; Streptococcus pneumoniae
This study was performed to measure early changes in the serotype distribution of pneumococci isolated from children with invasive disease during the 3-year period following the introduction of 10- and 13-valent pneumococcal conjugate vaccines (PCVs) in Korea. From January 2011 to December 2013 at 25 hospitals located throughout Korea, pneumococci were isolated among children who had invasive pneumococcal disease (IPD). Serotypes were determined using the Quellung reaction, and the change in serotype distribution was analyzed. Seventy-five cases of IPD were included. Eighty percent of patients were aged 3-59 months, and 32% had a comorbidity that increased the risk of pneumococcal infection. The most common serotypes were 19A (32.0%), 10A (8.0%), and 15C (6.7%). The PCV7 serotypes (4, 6B, 9V, 14, 18C, 19F, 23F, and 6A) accounted for 14.7% of the total isolates and the PCV13 minus PCV7 types (1, 3, 5, 7F and 19A) accounted for 32.0% of the total isolates. Serotype 19A was the only serotype in the PCV13 minus PCV7 group. The proportion of serotype 19A showed decreasing tendency from 37.5% in 2011 to 22.2% in 2013 (P = 0.309), while the proportion of non-PCV13 types showed increasing tendency from 45.8% in 2011 to 72.2% in 2013 (P = 0.108). Shortly after the introduction of extended-valent PCVs in Korea, serotype 19A continued to be the most common serotype causing IPD in children. Subsequently, the proportion of 19A decreased, and non-vaccine serotypes emerged as an important cause of IPD. The impact of extended-valent vaccines must be continuously monitored.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Soo(김동수)
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