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The Interaction Between Prenatal Exposure to Home Renovation and Reactive Oxygen Species Genes in Cord Blood IgE Response is Modified by Maternal Atopy.

Authors
 Jinho Yu  ;  Kangmo Ahn  ;  Youn Ho Shin  ;  Kyung Won Kim  ;  Dong In Suh  ;  Ho-Sung Yu  ;  Mi-Jin Kang  ;  Kyung-Shin Lee  ;  Seo Ah Hong  ;  Kil Yong Choi  ;  Eun Lee  ;  Song-I Yang  ;  Ju-Hee Seo  ;  Byoung-Ju Kim  ;  Hyo-Bin Kim  ;  So-Yeon Lee  ;  Suk-Joo Choi  ;  Soo-Young Oh  ;  Ja-Young Kwon  ;  Kyung-Ju Lee  ;  Hee Jin Park  ;  Pil Ryang Lee  ;  Hye-Sung Won  ;  Soo-Jong Hong  ;  the COCOA Study Group 
Citation
 Allergy Asthma & Immunology Research, Vol.8(1) : 41-48, 2016 
Journal Title
 Allergy Asthma & Immunology Research 
ISSN
 2092-7355 
Issue Date
2016
Keywords
Cord blood ; IgE ; gene-environment interaction ; prenatal ; reactive oxygen species ; renovation ; single nucleotide polymorphism
Abstract
PURPOSE: Although home renovation exposure during childhood has been identified as a risk factor for the development of allergy, there is limited information on the association between prenatal exposure to home renovation and cord blood (CB) IgE response. The aims of this study were to identify the effect of prenatal exposure to home renovation on CB IgE levels, and to investigate whether this exposure interacts with neonatal genes and whether the effect can be modified by maternal atopy. METHODS: This study included 1,002 mother-neonate pairs from the COhort for Childhood Origin of Asthma and allergic diseases (COCOA). Prenatal environmental factors were collected using a questionnaire. The levels of CB IgE were measured by the ImmunoCAP system, and DNA was extracted from CB. RESULTS: Exposure to home renovation during the prenatal period was associated with significantly higher levels of CB IgE only in neonates from atopic mothers, and the effect of renovation exposure on CB IgE levels persisted from 31 months before birth. Furthermore, prenatal exposure to home renovation increased the risk of CB IgE response interacting with polymorphisms of NRF2 and GSTP1 genes only in neonates from atopic mothers. CONCLUSIONS: Maternal atopy modified the effect of prenatal exposure to home renovation on CB serum IgE response as well as the interaction between the exposure and neonatal genes involved in the oxidative stress pathway. These findings suggest that the genetically susceptible offspring of atopic mothers may be more vulnerable to the effect of prenatal exposure to home renovation on the development of allergy.
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DOI
10.4168/aair.2016.8.1.41
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
권자영(Kwon, Ja Young) ORCID logo https://orcid.org/0000-0003-3009-6325
김경원(Kim, Kyung Won) ORCID logo https://orcid.org/0000-0003-4529-6135
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147036
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