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Bone health and its correlates in Korean prostate cancer patients receiving androgen deprivation therapy.

Authors
 Soo Hyun Kim  ;  Do Hwan Seong  ;  Sang Min Yoon  ;  Young Deuk Choi  ;  Youngkyu Song  ;  Hosook Song  ;  Eunju Choi 
Citation
 EUROPEAN JOURNAL OF ONCOLOGY NURSING, Vol.21 : 197-204, 2016 
Journal Title
 EUROPEAN JOURNAL OF ONCOLOGY NURSING 
ISSN
 1462-3889 
Issue Date
2016
MeSH
Aged ; Aged, 80 and over ; Androgen Antagonists/therapeutic use* ; Bone Density ; Cross-Sectional Studies ; Health Behavior ; Humans ; Life Style ; Male ; Middle Aged ; Osteoporosis/epidemiology* ; Prevalence ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/drug therapy* ; Republic of Korea ; Risk Factors ; Socioeconomic Factors
Keywords
Bone density ; Exercise ; Osteoporosis ; Prostate cancer ; Smoking
Abstract
PURPOSE: This study aimed to examine bone health status, identify factors associated with bone mineral density (BMD), and determine potential risk factors for osteoporosis in Korean prostate cancer patients receiving androgen deprivation therapy (ADT). METHODS: Using a cross-sectional descriptive design, we recruited 139 men with prostate cancer receiving ADT at two university-based hospitals in South Korea. Participants completed a self-reported questionnaire and underwent dual energy X-ray absorptiometry testing. BMD (gm/cm(2)), bone health status (normal BMD, osteopenia, and osteoporosis), and lifestyle variables (physical activity, smoking, and alcohol consumption) were measured. RESULTS: The prevalence in our sample was 49.6% for osteopenia and 17.3% for osteoporosis. In multivariate linear regression analyses, BMD was positively associated with body mass index, number of comorbidities, and level of physical activity and negatively associated with being unemployed or retired, having a lower monthly income, and being treated with gonadotropin-releasing hormone therapy alone. In logistic regression analyses, potential risk factors for osteoporosis were low monthly income (OR = 4.33, p = 0.011), receipt of radiation therapy (OR = 4.69, p = 0.018), and lack of regular physical activity (OR = 2.63, p = 0.035). CONCLUSIONS: Our results suggest that a proportion of prostate cancer survivors who are receiving ADT warrant monitoring to prevent osteoporosis, particularly men of lower economic status and those having lower levels of physical activity. Nurses can play an important role in screening these high risk groups.
Full Text
http://www.sciencedirect.com/science/article/pii/S1462388915300351
DOI
10.1016/j.ejon.2015.10.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147015
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