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Cyclooxygenase-2 Inhibitor Reduces Hepatic Stiffness in Pediatric Chronic Liver Disease Patients Following Kasai Portoenterostomy.

 Hye Kyung Chang  ;  Eun Young Chang  ;  Seonae Ryu  ;  Seok Joo Han 
 YONSEI MEDICAL JOURNAL, Vol.57(4) : 893-899, 2016 
Journal Title
Issue Date
Biliary Atresia/complications ; Biliary Atresia/enzymology ; Biliary Atresia/surgery* ; Child ; Child, Preschool ; Chronic Disease ; Cyclooxygenase 2 Inhibitors/therapeutic use* ; Female ; Humans ; Liver Cirrhosis/etiology ; Liver Cirrhosis/pathology ; Liver Cirrhosis/prevention & control* ; Male ; Portoenterostomy, Hepatic* ; Thiazines/therapeutic use* ; Thiazoles/therapeutic use*
Cyclooxygenase-2 inhibitors ; biliary atresia ; cholestatic liver disease ; hepatic fibrosis ; liver stiffness score
PURPOSE: The purpose of this study was to define the role of cyclooxygenase-2 inhibitors (COX-2i) in reducing hepatic fibrosis in pediatric patients with chronic liver disease. MATERIALS AND METHODS: From September 2009 to September 2010, patients over 2 years old who visited our outpatient clinic for follow-up to manage their chronic liver disease after Kasai portoenterostomy for biliary atresia, were included in this study. Volunteers were assigned to the study or control groups, according to their preference. A COX-2i was given to only the study group after obtaining consent. The degree of hepatic fibrosis (liver stiffness score, LSS) was prospectively measured using FibroScan, and liver function was examined using serum analysis before and after treatment. After 1 year, changes in LSSs and liver function were compared between the two groups. RESULTS: Twenty-five patients (18 females and 7 males) were enrolled in the study group. The control group included 44 patients (26 females and 18 males). After 1 year, the least square mean values for the LSSs were significantly decreased by 3.91±0.98 kPa (p=0.004) only in the study group. Serum total bilirubin did not decrease significantly in either group. CONCLUSION: COX-2i treatment improved the LSS in patients with chronic liver disease after Kasai portoenterostomy for biliary atresia.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Ryu, Seonae(류선애)
Chang, Eun Young(장은영)
Han, Seok Joo(한석주) ORCID logo https://orcid.org/0000-0001-5224-1437
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