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Plasma Neutrophil Gelatinase-associated Lipoprotein in Living Kidney Donors.

 Y.E. Yoon  ;  Y.I. Cho  ;  S.Y. Kim  ;  H.H. Lee  ;  K.H. Huh  ;  Y.S. Kim  ;  W.K. Han 
 Transplantation Proceedings, Vol.48(3) : 738-741, 2016 
Journal Title
 Transplantation Proceedings 
Issue Date
Acute Kidney Injury/blood ; Adult ; Biomarkers/blood ; Female ; Glomerular Filtration Rate ; Humans ; Kidney Transplantation* ; Lipocalin-2/blood* ; Living Donors* ; Male ; Nephrectomy ; Postoperative Period ; Preoperative Period ; Recovery of Function*
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker for acute kidney injury. This study was conducted to determine the clinical implications of perioperative plasma NGAL levels for renal function after living donor nephrectomy. METHODS: Between July 2013 and May 2014, 112 donors underwent live donor nephrectomy at our institution. Donor plasma NGAL levels were measured perioperatively for 6 months. The relationship between perioperative plasma NGAL and recovery of renal function was analyzed. Renal function was estimated with the Modification of Diet in Renal Disease formula. RESULTS: Mean preoperative NGAL was 62.1 ± 29.5 ng/mL. Plasma NGAL was most elevated 1 week postoperatively (218 ± 95.5 ng/mL), and stabilized after 1 month (122.9 ± 45.3 ng/mL). Preoperative plasma NGAL was not correlated with donor age or preoperative estimated glomerular filtration rates (eGFR), but was negatively correlated with 6-month eGFR (r = -0.458, P < .001). During the observation period, plasma NGAL at 1 week was most correlated with 6-month eGFR (r = -0.554, P < .001). An ROC curve analysis showed that age, preoperative eGFR, and 1-week postoperative plasma NGAL were highly predictive of developing of chronic kidney disease (CKD), defined as eGFR <60 mL/min/1.73 m(2), 6 months postoperatively (AUC = 0.91, P < .001). One-week postoperative plasma NGAL was also independently associated with CKD risk at 6 months (odds ratio: 1.13 for each 10 ng/mL increase, P = .013). CONCLUSION: Plasma NGAL becomes elevated after kidney donation and can provide information about acute kidney injury during the compensatory hyperfiltration period. Donors with increased perioperative plasma NGAL require close observation because their possibility of developing CKD after donation may be greater.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
김유선(Kim, Yu Seun) ORCID logo https://orcid.org/0000-0002-5105-1567
윤영은(Yoon, Young Eun)
이형호(Lee, Hyung Ho)
한웅규(Han, Woong Kyu) ORCID logo https://orcid.org/0000-0002-2527-4046
허규하(Huh, Kyu Ha) ORCID logo https://orcid.org/0000-0003-1364-6989
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