Cited 11 times in
Effect of Dexmedetomidine on Heart Rate-Corrected QT and Tpeak-Tend Intervals During Robot-Assisted Laparoscopic Prostatectomy With Steep Trendelenburg Position: A Prospective, Randomized, Double-Blinded, Controlled Study.
DC Field | Value | Language |
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dc.contributor.author | 고재철 | - |
dc.contributor.author | 김나영 | - |
dc.contributor.author | 김소연 | - |
dc.contributor.author | 나군호 | - |
dc.contributor.author | 한동우 | - |
dc.contributor.author | 홍정화 | - |
dc.date.accessioned | 2017-02-27T07:26:36Z | - |
dc.date.available | 2017-02-27T07:26:36Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146882 | - |
dc.description.abstract | Intraperitoneal insufflation of carbon dioxide may affect the sympathetic activity that leads to changes in ventricular repolarization. This in turn can result in changes of heart rate-corrected QT (QTc) interval and Tpeak-Tend (Tp-e) interval. Dexmedetomidine is a highly selective α2-receptor agonist and has potential antiarrhythmic properties. This prospective, randomized, double-blinded, controlled study evaluated the effects of dexmedetomidine administration on QTc and Tp-e intervals during robot-assisted laparoscopic prostatectomy with steep Trendelenburg position.Fifty patients scheduled for robot-assisted laparoscopic prostatectomy randomly received either a continuous infusion of dexmedetomidine at a rate of 0.3 μg/kg/hour, from anesthetic induction until the end of the Trendelenburg position (dexmedetomidine group; n = 25), or the same volume of normal saline (control group; n = 25). Anesthesia was maintained with sevoflurane and remifentanil. The primary and secondary goals were to evaluate the effect of dexmedetomidine on the QTc and Tp-e interval changes. Mean arterial pressure, heart rate, end-tidal CO2, and end-tidal sevoflurane concentrations were assessed as well.Forty-seven patients (94%) completed the study. Dexmedetomidine significantly attenuated QTc interval prolongation and reduced the Tp-e interval, even though the baseline values of the QTc and Tp-e intervals were similar between the 2 groups (PGroup × Time = 0.001 and 0.014, respectively). Twenty-two patients (96%) in the control group and 13 (54%) in the dexmedetomidine group had QTc interval prolongation of >20 ms from the baseline value during surgery (P = 0.001). The maximum QTc interval prolongation from the baseline value during surgery was 46 ± 21 ms in the control group and 24 ± 21 ms in the dexmedetomidine group (mean ± SD, P = 0.001). Mean arterial pressure and heart rate were comparable between the groups.Continuous infusion of dexmedetomidine at a rate of 0.3 μg/kg/hour significantly attenuated the QTc interval prolongation induced by CO2 pneumoperitoneum with steep Trendelenburg position. Furthermore, dexmedetomidine reduced the Tp-e interval. Thus, dexmedetomidine administration may be effective for patients who are susceptible to the development of ventricular arrhythmia during robot-assisted laparoscopic prostatectomy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Dexmedetomidine/pharmacology* | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Head-Down Tilt | - |
dc.subject.MESH | Heart Conduction System/drug effects* | - |
dc.subject.MESH | Heart Rate/drug effects* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypnotics and Sedatives/pharmacology* | - |
dc.subject.MESH | Intraoperative Care/methods | - |
dc.subject.MESH | Laparoscopy/methods | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Prostatectomy/methods* | - |
dc.subject.MESH | Robotic Surgical Procedures/methods | - |
dc.title | Effect of Dexmedetomidine on Heart Rate-Corrected QT and Tpeak-Tend Intervals During Robot-Assisted Laparoscopic Prostatectomy With Steep Trendelenburg Position: A Prospective, Randomized, Double-Blinded, Controlled Study. | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine | - |
dc.contributor.googleauthor | Na Young Kim | - |
dc.contributor.googleauthor | Dong Woo Han | - |
dc.contributor.googleauthor | Jae Chul Koh | - |
dc.contributor.googleauthor | Koon Ho Rha | - |
dc.contributor.googleauthor | Jung Hwa Hong | - |
dc.contributor.googleauthor | Jong Min Park | - |
dc.contributor.googleauthor | So Yeon Kim | - |
dc.identifier.doi | 10.1097/MD.0000000000003645 | - |
dc.contributor.localId | A04508 | - |
dc.contributor.localId | A00348 | - |
dc.contributor.localId | A00616 | - |
dc.contributor.localId | A01227 | - |
dc.contributor.localId | A04274 | - |
dc.contributor.localId | A04433 | - |
dc.relation.journalcode | J02214 | - |
dc.identifier.eissn | 1536-5964 | - |
dc.identifier.pmid | 27175685 | - |
dc.contributor.alternativeName | Koh, Jae Chul | - |
dc.contributor.alternativeName | Kim, Na Young | - |
dc.contributor.alternativeName | Kim, So Yeon | - |
dc.contributor.alternativeName | Rha, Koon Ho | - |
dc.contributor.alternativeName | Han, Dong Woo | - |
dc.contributor.alternativeName | Hong, Jung Hwa | - |
dc.contributor.affiliatedAuthor | Koh, Jae Chul | - |
dc.contributor.affiliatedAuthor | Kim, Na Young | - |
dc.contributor.affiliatedAuthor | Kim, So Yeon | - |
dc.contributor.affiliatedAuthor | Rha, Koon Ho | - |
dc.contributor.affiliatedAuthor | Han, Dong Woo | - |
dc.contributor.affiliatedAuthor | Hong, Jung Hwa | - |
dc.citation.volume | 95 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 3645 | - |
dc.identifier.bibliographicCitation | MEDICINE, Vol.95(19) : 3645, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 46449 | - |
dc.type.rims | ART | - |
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