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Clinical significance of changes in the corrected QT interval in stress-induced cardiomyopathy.

Authors
 Jung-Hee Lee  ;  Jae-Sun Uhm  ;  Dong Geum Shin  ;  Boyoung Joung  ;  Hui-Nam Pak  ;  Young-Guk Ko  ;  Geu-Ru Hong  ;  Moon-Hyoung Lee 
Citation
 KOREAN JOURNAL OF INTERNAL MEDICINE, Vol.31(3) : 507-516, 2016 
Journal Title
 KOREAN JOURNAL OF INTERNAL MEDICINE 
ISSN
 1226-3303 
Issue Date
2016
MeSH
Action Potentials ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/etiology* ; Arrhythmias, Cardiac/mortality ; Arrhythmias, Cardiac/physiopathology ; Echocardiography ; Electrocardiography ; Female ; Heart Conduction System/physiopathology* ; Heart Rate* ; Hospital Mortality ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Predictive Value of Tests ; Recovery of Function ; Retrospective Studies ; Risk Factors ; Takotsubo Cardiomyopathy/complications* ; Takotsubo Cardiomyopathy/diagnosis ; Takotsubo Cardiomyopathy/mortality ; Takotsubo Cardiomyopathy/physiopathology ; Time Factors ; Young Adult
Keywords
Electrocardiography ; Mortality ; QTc interval ; Takotsubo cardiomyopathy
Abstract
BACKGROUND/AIMS: Although transient changes in the electrocardiogram (ECG) of patients with stress-induced cardiomyopathy (SCMP) are common, there are little data about ECG changes in patients with SCMP and the clinical implications of these variations. METHODS: We investigated a total of 128 patients (age, 63.2 ± 15.4 years; female, 60.9%) diagnosed with SCMP. We compared the ECGs taken after SCMP diagnosis and during the recovery phase to those taken before SCMP diagnosis under baseline conditions. All patients were divided into two groups according to corrected QT (QTc) interval changes: recovered QTc group (QTc in SCMP > QTc in recovery phase, n = 77) and nonrecovered QTc group (QTc in SCMP ≤ QTc in recovery phase, n = 51). RESULTS: In comparison of baseline, SCMP, and recovery phase, we found the mean heart rate (81.5 ± 18.7, 96.8 ± 25.3, and 83.0 ± 19.4/min, respectively; p < 0.001), frequencies of ST segment elevation (0.0%, 8.6%, and 1.6%, p = 0.004), ST segment depression (0.0%, 6.3%, and 1.6%, p = 0.007), T wave inversion (4.4 %, 43.8%, and 61.7%, p < 0.001), and QTc (447.4 ± 35.3, 488.9 ± 67.1, and 468.0 ± 49.5, p < 0.001) showed significant changes. In-hospital mortality (9.1% vs. 25.5%, p = 0.012) and critical care (54.5% vs. 72.5%, p = 0.040) occurred more frequently in the nonrecovered QTc group than in recovered QTc group. CONCLUSIONS: The QTc can be prolonged in patients with SCMP. Short-term mortality was increased in patients where the QTc did not recover.
Files in This Item:
T201601466.pdf Download
DOI
10.3904/kjim.2015.330
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Pak, Hui Nam(박희남) ORCID logo https://orcid.org/0000-0002-3256-3620
Uhm, Jae Sun(엄재선) ORCID logo https://orcid.org/0000-0002-1611-8172
Lee, Moon Hyoung(이문형) ORCID logo https://orcid.org/0000-0002-7268-0741
Joung, Bo Young(정보영) ORCID logo https://orcid.org/0000-0001-9036-7225
Hong, Geu Ru(홍그루) ORCID logo https://orcid.org/0000-0003-4981-3304
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146851
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