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The Effects of Adherence to Non-Steroidal Anti-Inflammatory Drugs and Factors Influencing Drug Adherence in Patients with Knee Osteoarthritis.

Authors
 Kwan Kyu Park  ;  Choong Hyeok Choi  ;  Chul-Won Ha  ;  Myung Chul Lee 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.31(5) : 795-800, 2016 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2016
MeSH
Age Factors ; Aged ; Aged, 80 and over ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use* ; Female ; Humans ; Knee Joint/pathology ; Logistic Models ; Male ; Medication Adherence* ; Osteoarthritis, Knee/drug therapy* ; Pain Measurement ; Prospective Studies ; Sex Factors
Keywords
Anti-Inflammatory Agents, Non-Steroidal ; Osteoarthritis, Knee ; Patient Adherence
Abstract
We aimed to compare the clinical outcomes of knee osteoarthritis patients according to drug adherence; and to find out the factors the affecting those outcomes. We analyzed the drug adherence and clinical outcomes in 1,334 primary knee osteoarthritis patients who took non-steroidal anti-inflammatory drugs (NSAIDs) for 3 weeks. Clinical outcomes of Pain Numeric Rating Scale (NRS), Knee injury and Osteoarthritis Outcome Score (KOOS) and EQ-5D were compared at baseline and 3 weeks' follow-up between the two groups of adherent group and non-adherent group (1,167 vs. 167 patients). Logistic regression analysis was performed to examine the factors affecting the adherence, and the reasons for the non-adherence were asked. The follow-up clinical outcomes of NRS and KOOS symptom, pain and activity of daily life were significantly higher in the adherence group (P = 0.003, P = 0.048, P = 0.005, and P = 0.003, respectively). The adherence was better in the elderly and in the male group (P = 0.042 and P = 0.034, respectively) and the top reason for no strict adherence was "symptom improved" (21.5%) followed by side effects. In this study, the patients with better adherence to NSAIDs showed better outcomes compared to those with poor adherence. This study can contribute to the patient education for the pharmacological treatment in knee OA patients.
Files in This Item:
T201601463.pdf Download
DOI
10.3346/jkms.2016.31.5.795
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Kwan Kyu(박관규) ORCID logo https://orcid.org/0000-0003-0514-3257
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146848
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